Abstract
A minority of centroblastic and centroblastic/centrocytic cell lymphomas are accompanied by a prominent epithelioid cell response and were suggested to be a distinct variant of B-cell lymphoma of germinal center cell origin. To confirm the clinicopathologic significance of these mainly large B-cell lymphomas with an epithelioid cell response (LBCL-ER), we reviewed 50 patients with LBCL-ER and compared the results with those of 167 other diffuse large B-cell lymphomas (DLBCL) and 94 follicular lymphomas (FL) without epithelioid response. The patients with LBCL-ER showed a higher age distribution (median 71, P = .03), a female predominance (M:F = 18:32, P = .001) and less frequent involvement of extranodal sites > 1 (P = .004) compared with those with DLBCL, and presented with a bulky mass of the affected lymph nodes in 54% of cases. They were also older (P = .0006) and more associated with the aggressive clinical factors such as serum LDH level and International Prognostic Index score than those with FL. Histologically, nine cases (18%) partially showed a follicular growth pattern, and the others (82%) were occupied by a diffuse growth pattern. The epithelioid cells were accumulated in large demarcated masses, partially imparting a lymphoepithelioid (Lennert) lymphoma-like appearance to some portions of the lesions in every case. Immunohistochemically, LBCR-ER was positive for CD20 in every case, CD10 in 43% of the cases, and BCL-2 in 56%. None of the tumor cells in the 40 cases tested expressed CD5 antigen. Immunostaining also often highlighted the remnants of the follicular dendritic cell network. The BCL-2 gene rearrangement was detected in only 19% of the cases examined. The survival curve of the cases of LBCL-ER was almost identical with that of DLBCL and was significantly inferior to that of FL. The centroblastic and centroblastic/centrocytic lymphoma with an epithelioid cell response may be regarded as the morphologic variant of DLBCL preferentially arising in the aged population and reflecting the disease progression of FL.
| Original language | English |
|---|---|
| Pages (from-to) | 750-758 |
| Number of pages | 9 |
| Journal | Modern Pathology |
| Volume | 15 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2002 |
| Externally published | Yes |
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Keywords
- Centroblastic lymphoma
- Centroblastic/centrocytic lymphoma
- Diffuse large B-cell lymphoma
- Epithelioid granulomatous response
- Follicular large cell lymphoma
- Lymphoma progression
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Centroblastic and centroblastic/centrocytic lymphoma associated with a prominent epithelioid granulomatous response : A clinicopathologic study of 50 cases. / Kojima, Masaru; Nakamura, Shigeo; Ichimura, Koichi; Suzuki, Ritsuro; Kagami, Yoshitoki; Kondo, Eisei; Motoori, Tadashi; Hosomura, Yasuo; Oyama, Tetsunari; Itoh, Hideaki; Ban, Satoshi; Yoshida, Katsue; Ohno, Yoshihiro; Shimizu, Kazuhiko; Masawa, Nobuhide; Sugihara, Shiro.
In: Modern Pathology, Vol. 15, No. 7, 2002, p. 750-758.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Centroblastic and centroblastic/centrocytic lymphoma associated with a prominent epithelioid granulomatous response
T2 - A clinicopathologic study of 50 cases
AU - Kojima, Masaru
AU - Nakamura, Shigeo
AU - Ichimura, Koichi
AU - Suzuki, Ritsuro
AU - Kagami, Yoshitoki
AU - Kondo, Eisei
AU - Motoori, Tadashi
AU - Hosomura, Yasuo
AU - Oyama, Tetsunari
AU - Itoh, Hideaki
AU - Ban, Satoshi
AU - Yoshida, Katsue
AU - Ohno, Yoshihiro
AU - Shimizu, Kazuhiko
AU - Masawa, Nobuhide
AU - Sugihara, Shiro
PY - 2002
Y1 - 2002
N2 - A minority of centroblastic and centroblastic/centrocytic cell lymphomas are accompanied by a prominent epithelioid cell response and were suggested to be a distinct variant of B-cell lymphoma of germinal center cell origin. To confirm the clinicopathologic significance of these mainly large B-cell lymphomas with an epithelioid cell response (LBCL-ER), we reviewed 50 patients with LBCL-ER and compared the results with those of 167 other diffuse large B-cell lymphomas (DLBCL) and 94 follicular lymphomas (FL) without epithelioid response. The patients with LBCL-ER showed a higher age distribution (median 71, P = .03), a female predominance (M:F = 18:32, P = .001) and less frequent involvement of extranodal sites > 1 (P = .004) compared with those with DLBCL, and presented with a bulky mass of the affected lymph nodes in 54% of cases. They were also older (P = .0006) and more associated with the aggressive clinical factors such as serum LDH level and International Prognostic Index score than those with FL. Histologically, nine cases (18%) partially showed a follicular growth pattern, and the others (82%) were occupied by a diffuse growth pattern. The epithelioid cells were accumulated in large demarcated masses, partially imparting a lymphoepithelioid (Lennert) lymphoma-like appearance to some portions of the lesions in every case. Immunohistochemically, LBCR-ER was positive for CD20 in every case, CD10 in 43% of the cases, and BCL-2 in 56%. None of the tumor cells in the 40 cases tested expressed CD5 antigen. Immunostaining also often highlighted the remnants of the follicular dendritic cell network. The BCL-2 gene rearrangement was detected in only 19% of the cases examined. The survival curve of the cases of LBCL-ER was almost identical with that of DLBCL and was significantly inferior to that of FL. The centroblastic and centroblastic/centrocytic lymphoma with an epithelioid cell response may be regarded as the morphologic variant of DLBCL preferentially arising in the aged population and reflecting the disease progression of FL.
AB - A minority of centroblastic and centroblastic/centrocytic cell lymphomas are accompanied by a prominent epithelioid cell response and were suggested to be a distinct variant of B-cell lymphoma of germinal center cell origin. To confirm the clinicopathologic significance of these mainly large B-cell lymphomas with an epithelioid cell response (LBCL-ER), we reviewed 50 patients with LBCL-ER and compared the results with those of 167 other diffuse large B-cell lymphomas (DLBCL) and 94 follicular lymphomas (FL) without epithelioid response. The patients with LBCL-ER showed a higher age distribution (median 71, P = .03), a female predominance (M:F = 18:32, P = .001) and less frequent involvement of extranodal sites > 1 (P = .004) compared with those with DLBCL, and presented with a bulky mass of the affected lymph nodes in 54% of cases. They were also older (P = .0006) and more associated with the aggressive clinical factors such as serum LDH level and International Prognostic Index score than those with FL. Histologically, nine cases (18%) partially showed a follicular growth pattern, and the others (82%) were occupied by a diffuse growth pattern. The epithelioid cells were accumulated in large demarcated masses, partially imparting a lymphoepithelioid (Lennert) lymphoma-like appearance to some portions of the lesions in every case. Immunohistochemically, LBCR-ER was positive for CD20 in every case, CD10 in 43% of the cases, and BCL-2 in 56%. None of the tumor cells in the 40 cases tested expressed CD5 antigen. Immunostaining also often highlighted the remnants of the follicular dendritic cell network. The BCL-2 gene rearrangement was detected in only 19% of the cases examined. The survival curve of the cases of LBCL-ER was almost identical with that of DLBCL and was significantly inferior to that of FL. The centroblastic and centroblastic/centrocytic lymphoma with an epithelioid cell response may be regarded as the morphologic variant of DLBCL preferentially arising in the aged population and reflecting the disease progression of FL.
KW - Centroblastic lymphoma
KW - Centroblastic/centrocytic lymphoma
KW - Diffuse large B-cell lymphoma
KW - Epithelioid granulomatous response
KW - Follicular large cell lymphoma
KW - Lymphoma progression
UR - http://www.scopus.com/inward/record.url?scp=18444382940&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=18444382940&partnerID=8YFLogxK
U2 - 10.1097/01.MP.0000018980.83088.D3
DO - 10.1097/01.MP.0000018980.83088.D3
M3 - Article
C2 - 12118113
AN - SCOPUS:18444382940
VL - 15
SP - 750
EP - 758
JO - Modern Pathology
JF - Modern Pathology
SN - 0893-3952
IS - 7
ER -