Central orexin facilitates gastric relaxation and contractility in rats

Motoi Kobashi, Yuichi Furudono, Ryuji Matsuo, Takashi Yamamoto

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The effects of the intracisternal administration of synthetic orexin-A (3 nmol) on gastric motility were examined in rats. The administration of orexin but not a vehicle induced relaxation of the proximal stomach lasting for more than 30 min. Phasic contractions in the distal stomach were facilitated in response to the administration of orexin but not a vehicle. Facilitation in the distal stomach was not observed in the animals which underwent the sectioning of the bilateral vagi at the subdiaphragmatic level. Relaxation of the proximal stomach was observed in vagotomized animals but the magnitude of relaxation was significantly smaller than that in intact animals. These results suggest that central orexin facilitates distal stomach motility and relaxation of the proximal stomach via vagi.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalNeuroscience Letters
Volume332
Issue number3
DOIs
Publication statusPublished - Nov 8 2002

Keywords

  • Gastric
  • Motility
  • Orexin
  • Relaxation
  • Stomach
  • Vagus

ASJC Scopus subject areas

  • Neuroscience(all)

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