Central ghrelin inhibits reflex swallowing elicited by activation of the superior laryngeal nerve in the rat

Motoi Kobashi, Song Yu Xuan, Masako Fujita, Yoshihiro Mitoh, Ryuji Matsuo

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effect of ghrelin on rhythmic reflex swallowing was examined in urethane-chloralose anesthetized rats. Swallowing was monitored by recording electromyographic activities of the suprahyoid muscle. Fourth ventricular administration of ghrelin decreased swallowing frequency during electrical stimulation of the central cut end of the superior laryngeal nerve (SLN stimulation). A significant decrease in swallowing frequency was observed after ghrelin administration at doses of 3, 10, 30 and 100 pmol. The administration of ghrelin with growth hormone secretagogue receptor antagonist ([D-Lys3] GHRP-6) did not change swallowing frequency during SLN stimulation. Neither mean blood pressure nor heart rate changed after the administration of 10 pmol ghrelin. Bilateral vagotomy did not disrupt the ghrelin response. These observations indicate that the ghrelin response does not depend on either cardiovascular or abdominal responses. Microinjection of ghrelin (0.3 pmol) into the vicinity of the solitary tract inhibited swallowing induced by SLN stimulation. Fourth ventricular administration of orexin-A (3 nmol) also inhibited reflex swallowing elicited by SLN stimulation. These results suggest that ghrelin and other orexigenic peptides inhibit reflex swallowing by modifying neural activities of the dorsal medulla where the swallowing center is housed.

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalRegulatory Peptides
Volume160
Issue number1-3
DOIs
Publication statusPublished - Feb 25 2010

Fingerprint

Laryngeal Nerves
Ghrelin
Deglutition
Reflex
Rats
Chemical activation
Ghrelin Receptor
Chloralose
Vagotomy
Urethane
Blood pressure
Microinjections
Electric Stimulation
Muscle
Heart Rate
Blood Pressure
Muscles

Keywords

  • Appetite
  • Deglutition
  • Medulla
  • Mylohyoid
  • Orexin

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Central ghrelin inhibits reflex swallowing elicited by activation of the superior laryngeal nerve in the rat. / Kobashi, Motoi; Xuan, Song Yu; Fujita, Masako; Mitoh, Yoshihiro; Matsuo, Ryuji.

In: Regulatory Peptides, Vol. 160, No. 1-3, 25.02.2010, p. 19-25.

Research output: Contribution to journalArticle

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