Central gastrin inhibits feeding behavior and food passage in neonatal chicks

Mitsuhiro Furuse, Ryutarou Ao, Takashi Bungo, Ryuichi Ando, Masataka Shimojo, Yasuhisa Masuda, Noboru Saito

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The gastrin/cholecystokinin (CCK) family is recognized as the principal family of hormones involved in regulation of the gastrointestinal tract. CCK is recognized as a satiety hormone in mammalian species, but it has been suggested that gastrin rather CCK may have an important role in controlling feeding behavior in the neonatal chick through a poorly developed blood brain barrier. So far, however, there is no direct evidence that central gastrin inhibits food intake in neonatal chicks. The aim of this study was to elucidate whether central administration of gastrin 1) inhibits feeding behavior and 2) alters food passage from the crop. The effects of central administration of gastrin on food intake were investigated in experiment 1. Birds (2-day-old) were food-deprived for 3 h and then gastrin or saline was injected intracerebroventricularly. Gastrin strongly inhibited food intake in a dose-dependent fashion for 2 h. Thereafter, the effects of central gastrin on feeding behavior and serum corticosterone concentration were examined in experiment 2. Following central administration of gastrin, food intake was depressed and pecking behavior was inhibited. Serum corticosterone concentration was not altered by central administration of gastrin. The influence of central gastrin on food passage from the crop was investigated in experiment 3. Central administration of gastrin clearly delayed food passage. In conclusion, central gastrin appears to have a strong effect for the satiety and gastrointestinal motility in the neonatal chick.

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalLife Sciences
Volume65
Issue number3
DOIs
Publication statusPublished - Jun 11 1999
Externally publishedYes

Keywords

  • Chicken
  • Corticosterone
  • Feeding behavior
  • Food passage
  • Gastrin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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