Central gastrin inhibits feeding behavior and food passage in neonatal chicks

Mitsuhiro Furuse, Ryutarou Ao, Takashi Bungo, Ryuichi Ando, Masataka Shimojo, Yasuhisa Masuda, Noboru Saito

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The gastrin/cholecystokinin (CCK) family is recognized as the principal family of hormones involved in regulation of the gastrointestinal tract. CCK is recognized as a satiety hormone in mammalian species, but it has been suggested that gastrin rather CCK may have an important role in controlling feeding behavior in the neonatal chick through a poorly developed blood brain barrier. So far, however, there is no direct evidence that central gastrin inhibits food intake in neonatal chicks. The aim of this study was to elucidate whether central administration of gastrin 1) inhibits feeding behavior and 2) alters food passage from the crop. The effects of central administration of gastrin on food intake were investigated in experiment 1. Birds (2-day-old) were food-deprived for 3 h and then gastrin or saline was injected intracerebroventricularly. Gastrin strongly inhibited food intake in a dose-dependent fashion for 2 h. Thereafter, the effects of central gastrin on feeding behavior and serum corticosterone concentration were examined in experiment 2. Following central administration of gastrin, food intake was depressed and pecking behavior was inhibited. Serum corticosterone concentration was not altered by central administration of gastrin. The influence of central gastrin on food passage from the crop was investigated in experiment 3. Central administration of gastrin clearly delayed food passage. In conclusion, central gastrin appears to have a strong effect for the satiety and gastrointestinal motility in the neonatal chick.

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalLife Sciences
Volume65
Issue number3
DOIs
Publication statusPublished - Jun 11 1999
Externally publishedYes

Fingerprint

Gastrins
Feeding Behavior
Food
Cholecystokinin
Eating
Corticosterone
Crops
Hormones
Gastrointestinal Motility
Experiments
Birds
Blood-Brain Barrier
Serum
Gastrointestinal Tract

Keywords

  • Chicken
  • Corticosterone
  • Feeding behavior
  • Food passage
  • Gastrin

ASJC Scopus subject areas

  • Pharmacology

Cite this

Central gastrin inhibits feeding behavior and food passage in neonatal chicks. / Furuse, Mitsuhiro; Ao, Ryutarou; Bungo, Takashi; Ando, Ryuichi; Shimojo, Masataka; Masuda, Yasuhisa; Saito, Noboru.

In: Life Sciences, Vol. 65, No. 3, 11.06.1999, p. 305-311.

Research output: Contribution to journalArticle

Furuse, M, Ao, R, Bungo, T, Ando, R, Shimojo, M, Masuda, Y & Saito, N 1999, 'Central gastrin inhibits feeding behavior and food passage in neonatal chicks', Life Sciences, vol. 65, no. 3, pp. 305-311. https://doi.org/10.1016/S0024-3205(99)00249-0
Furuse M, Ao R, Bungo T, Ando R, Shimojo M, Masuda Y et al. Central gastrin inhibits feeding behavior and food passage in neonatal chicks. Life Sciences. 1999 Jun 11;65(3):305-311. https://doi.org/10.1016/S0024-3205(99)00249-0
Furuse, Mitsuhiro ; Ao, Ryutarou ; Bungo, Takashi ; Ando, Ryuichi ; Shimojo, Masataka ; Masuda, Yasuhisa ; Saito, Noboru. / Central gastrin inhibits feeding behavior and food passage in neonatal chicks. In: Life Sciences. 1999 ; Vol. 65, No. 3. pp. 305-311.
@article{ac5d57bdf08945fdb629079dc8acb17e,
title = "Central gastrin inhibits feeding behavior and food passage in neonatal chicks",
abstract = "The gastrin/cholecystokinin (CCK) family is recognized as the principal family of hormones involved in regulation of the gastrointestinal tract. CCK is recognized as a satiety hormone in mammalian species, but it has been suggested that gastrin rather CCK may have an important role in controlling feeding behavior in the neonatal chick through a poorly developed blood brain barrier. So far, however, there is no direct evidence that central gastrin inhibits food intake in neonatal chicks. The aim of this study was to elucidate whether central administration of gastrin 1) inhibits feeding behavior and 2) alters food passage from the crop. The effects of central administration of gastrin on food intake were investigated in experiment 1. Birds (2-day-old) were food-deprived for 3 h and then gastrin or saline was injected intracerebroventricularly. Gastrin strongly inhibited food intake in a dose-dependent fashion for 2 h. Thereafter, the effects of central gastrin on feeding behavior and serum corticosterone concentration were examined in experiment 2. Following central administration of gastrin, food intake was depressed and pecking behavior was inhibited. Serum corticosterone concentration was not altered by central administration of gastrin. The influence of central gastrin on food passage from the crop was investigated in experiment 3. Central administration of gastrin clearly delayed food passage. In conclusion, central gastrin appears to have a strong effect for the satiety and gastrointestinal motility in the neonatal chick.",
keywords = "Chicken, Corticosterone, Feeding behavior, Food passage, Gastrin",
author = "Mitsuhiro Furuse and Ryutarou Ao and Takashi Bungo and Ryuichi Ando and Masataka Shimojo and Yasuhisa Masuda and Noboru Saito",
year = "1999",
month = "6",
day = "11",
doi = "10.1016/S0024-3205(99)00249-0",
language = "English",
volume = "65",
pages = "305--311",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Central gastrin inhibits feeding behavior and food passage in neonatal chicks

AU - Furuse, Mitsuhiro

AU - Ao, Ryutarou

AU - Bungo, Takashi

AU - Ando, Ryuichi

AU - Shimojo, Masataka

AU - Masuda, Yasuhisa

AU - Saito, Noboru

PY - 1999/6/11

Y1 - 1999/6/11

N2 - The gastrin/cholecystokinin (CCK) family is recognized as the principal family of hormones involved in regulation of the gastrointestinal tract. CCK is recognized as a satiety hormone in mammalian species, but it has been suggested that gastrin rather CCK may have an important role in controlling feeding behavior in the neonatal chick through a poorly developed blood brain barrier. So far, however, there is no direct evidence that central gastrin inhibits food intake in neonatal chicks. The aim of this study was to elucidate whether central administration of gastrin 1) inhibits feeding behavior and 2) alters food passage from the crop. The effects of central administration of gastrin on food intake were investigated in experiment 1. Birds (2-day-old) were food-deprived for 3 h and then gastrin or saline was injected intracerebroventricularly. Gastrin strongly inhibited food intake in a dose-dependent fashion for 2 h. Thereafter, the effects of central gastrin on feeding behavior and serum corticosterone concentration were examined in experiment 2. Following central administration of gastrin, food intake was depressed and pecking behavior was inhibited. Serum corticosterone concentration was not altered by central administration of gastrin. The influence of central gastrin on food passage from the crop was investigated in experiment 3. Central administration of gastrin clearly delayed food passage. In conclusion, central gastrin appears to have a strong effect for the satiety and gastrointestinal motility in the neonatal chick.

AB - The gastrin/cholecystokinin (CCK) family is recognized as the principal family of hormones involved in regulation of the gastrointestinal tract. CCK is recognized as a satiety hormone in mammalian species, but it has been suggested that gastrin rather CCK may have an important role in controlling feeding behavior in the neonatal chick through a poorly developed blood brain barrier. So far, however, there is no direct evidence that central gastrin inhibits food intake in neonatal chicks. The aim of this study was to elucidate whether central administration of gastrin 1) inhibits feeding behavior and 2) alters food passage from the crop. The effects of central administration of gastrin on food intake were investigated in experiment 1. Birds (2-day-old) were food-deprived for 3 h and then gastrin or saline was injected intracerebroventricularly. Gastrin strongly inhibited food intake in a dose-dependent fashion for 2 h. Thereafter, the effects of central gastrin on feeding behavior and serum corticosterone concentration were examined in experiment 2. Following central administration of gastrin, food intake was depressed and pecking behavior was inhibited. Serum corticosterone concentration was not altered by central administration of gastrin. The influence of central gastrin on food passage from the crop was investigated in experiment 3. Central administration of gastrin clearly delayed food passage. In conclusion, central gastrin appears to have a strong effect for the satiety and gastrointestinal motility in the neonatal chick.

KW - Chicken

KW - Corticosterone

KW - Feeding behavior

KW - Food passage

KW - Gastrin

UR - http://www.scopus.com/inward/record.url?scp=0033546305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033546305&partnerID=8YFLogxK

U2 - 10.1016/S0024-3205(99)00249-0

DO - 10.1016/S0024-3205(99)00249-0

M3 - Article

C2 - 10447216

AN - SCOPUS:0033546305

VL - 65

SP - 305

EP - 311

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 3

ER -