Central administration of prolactin-releasing peptide shifts the utilities of metabolic fuels from carbohydrate to lipids in chicks

Tetsuya Tachibana, Shunsuke Moriyama, Md Sakirul Islam Khan, Tatsuya Sakamoto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We have recently identified prolactin (PRL)-releasing peptides (PrRPs) and their stimulating effects on feeding behavior in chicks. To investigate further metabolic functions of PrRP, the present study was performed to clarify whether intracerebroventricular (ICV) injection of PrRP31, an active form of PrRP in chicks, affects heat production (HP), respiratory quotient (RQ) and plasma concentrations of metabolic fuels in chicks. The ICV injection of PrRP31 (94 and 375. pmol) did not affect HP but significantly lowered RQ. The change in RQ implies that PrRP31 shifted the utility of metabolic fuels in the body. This idea was confirmed by subsequent results in which ICV injection of PrRP31 significantly reduced glucose but increased non-esterified fatty acid concentrations in plasma. These shifts in blood metabolic fuels would not be through the increased plasma insulin, because the ICV injection of PrRP31 significantly decreased plasma insulin concentration. On the other hand, ICV injection of another orexigenic peptide, neuropeptide Y (NPY) also induced the insulin release and the metabolic effects were similar to those of PrRP31. Because ICV injection of PrRP31 increased NPY mRNA in the diencephalon, the NPY may mediate the metabolic functions of PrRP31. In summary, the present study suggests that central PrRP31 shifts the utilities of peripheral energy sources, which is not via hyperinsulinemia but via the diencephalon.

Original languageEnglish
Pages (from-to)40-45
Number of pages6
JournalPhysiology and Behavior
Volume120
DOIs
Publication statusPublished - Aug 15 2013

Fingerprint

Prolactin-Releasing Hormone
Carbohydrates
Lipids
Injections
Neuropeptide Y
Diencephalon
Thermogenesis
Insulin
Peptides
Plasma
Hyperinsulinism
Feeding Behavior

Keywords

  • Chick
  • Heat production
  • Insulin
  • Intracerebroventricular
  • Prolactin-releasing peptide
  • Respiratory quotient

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Experimental and Cognitive Psychology
  • Philosophy

Cite this

Central administration of prolactin-releasing peptide shifts the utilities of metabolic fuels from carbohydrate to lipids in chicks. / Tachibana, Tetsuya; Moriyama, Shunsuke; Khan, Md Sakirul Islam; Sakamoto, Tatsuya.

In: Physiology and Behavior, Vol. 120, 15.08.2013, p. 40-45.

Research output: Contribution to journalArticle

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