Central administration of glucagon suppresses food intake in chicks

Kazuhisa Honda, Hiroshi Kamisoyama, Noboru Saito, Yohei Kurose, Kunio Sugahara, Shin Hasegawa

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Food intake in chickens is regulated in a manner similar to that in mammals. Corticotropin-releasing factor (CRF), which increases the plasma corticosterone concentration, plays an important role as a mediator of many appetite-suppressive peptides in the central nervous system in both species. Central administration of glucagon suppresses food intake in rats. However, the anorexigenic action of glucagon in chicks has not yet been identified. In the present study, we investigated the effects of central administration of glucagon on food intake in chicks. Intracerebroventricular administration of glucagon in chicks significantly suppressed food intake and significantly induced hyperglycemia. In contrast, peripheral administration of the same dose of glucagon did not influence food intake and plasma glucose concentration. These results suggest that glucagon functions in chicks as an appetite-suppressive peptide in the central nervous system. Intracerebroventricular administration of glucagon in chicks also significantly increased CRF mRNA expression and plasma corticosterone concentration, suggesting that CRF acts as a downstream molecule for a glucagon-induced appetite-suppressive pathway in chicks. It is likely that the induction of hyperglycemia by central administration of glucagon is involved in its anorexigenic action, because peripheral administration of glucose in chicks suppressed food intake. These results suggest that CRF- and/or hyperglycemia-mediated pathways are involved in the anorexigenic action of glucagon in chicks.

Original languageEnglish
Pages (from-to)198-201
Number of pages4
JournalNeuroscience Letters
Volume416
Issue number2
DOIs
Publication statusPublished - Apr 12 2007
Externally publishedYes

Fingerprint

Glucagon
Eating
Corticotropin-Releasing Hormone
Appetite
Hyperglycemia
Corticosterone
Central Nervous System
Glucose
Peptides
Mammals
Chickens
Messenger RNA

Keywords

  • Chicken
  • Food intake
  • Glucagon
  • Hyperglycemia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Honda, K., Kamisoyama, H., Saito, N., Kurose, Y., Sugahara, K., & Hasegawa, S. (2007). Central administration of glucagon suppresses food intake in chicks. Neuroscience Letters, 416(2), 198-201. https://doi.org/10.1016/j.neulet.2007.02.011

Central administration of glucagon suppresses food intake in chicks. / Honda, Kazuhisa; Kamisoyama, Hiroshi; Saito, Noboru; Kurose, Yohei; Sugahara, Kunio; Hasegawa, Shin.

In: Neuroscience Letters, Vol. 416, No. 2, 12.04.2007, p. 198-201.

Research output: Contribution to journalArticle

Honda, K, Kamisoyama, H, Saito, N, Kurose, Y, Sugahara, K & Hasegawa, S 2007, 'Central administration of glucagon suppresses food intake in chicks', Neuroscience Letters, vol. 416, no. 2, pp. 198-201. https://doi.org/10.1016/j.neulet.2007.02.011
Honda, Kazuhisa ; Kamisoyama, Hiroshi ; Saito, Noboru ; Kurose, Yohei ; Sugahara, Kunio ; Hasegawa, Shin. / Central administration of glucagon suppresses food intake in chicks. In: Neuroscience Letters. 2007 ; Vol. 416, No. 2. pp. 198-201.
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