Cellular and molecular actions of CCN2/CTGF and its role under physiological and pathological conditions

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

CCN family protein 2 (CCN2), also widely known as connective tissue growth factor (CTGF), is one of the founding members of the CCN family of matricellular proteins. Extensive investigation on CCN2 over decades has revealed the novel molecular action and functional properties of this unique signalling modulator. By its interaction with multiple molecular counterparts, CCN2 yields highly diverse and context-dependent biological outcomes in a variety of microenvironments. Nowadays, CCN2 is recognized to conduct the harmonized development of relevant tissues, such as cartilage and bone, in the skeletal system, by manipulating extracellular signalling molecules involved therein by acting as a hub through a web. However, on the other hand, CCN2 occasionally plays profound roles in major human biological disorders, including fibrosis and malignancies in major organs and tissues, by modulating the actions of key molecules involved in these clinical entities. In this review, the physiological and pathological roles of this unique protein are comprehensively summarized from a molecular network-based viewpoint of CCN2 functionalities.

Original languageEnglish
Pages (from-to)181-196
Number of pages16
JournalClinical Science
Volume128
Issue number3
DOIs
Publication statusPublished - 2014

Fingerprint

CCN Intercellular Signaling Proteins
Connective Tissue Growth Factor
Cartilage
Fibrosis
Bone and Bones
Neoplasms
Proteins

Keywords

  • CCN family
  • Fibrosis
  • Gene regulation
  • Malignancy
  • Matricellular protein

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{fff68c982b784981b9021b6a27b008b9,
title = "Cellular and molecular actions of CCN2/CTGF and its role under physiological and pathological conditions",
abstract = "CCN family protein 2 (CCN2), also widely known as connective tissue growth factor (CTGF), is one of the founding members of the CCN family of matricellular proteins. Extensive investigation on CCN2 over decades has revealed the novel molecular action and functional properties of this unique signalling modulator. By its interaction with multiple molecular counterparts, CCN2 yields highly diverse and context-dependent biological outcomes in a variety of microenvironments. Nowadays, CCN2 is recognized to conduct the harmonized development of relevant tissues, such as cartilage and bone, in the skeletal system, by manipulating extracellular signalling molecules involved therein by acting as a hub through a web. However, on the other hand, CCN2 occasionally plays profound roles in major human biological disorders, including fibrosis and malignancies in major organs and tissues, by modulating the actions of key molecules involved in these clinical entities. In this review, the physiological and pathological roles of this unique protein are comprehensively summarized from a molecular network-based viewpoint of CCN2 functionalities.",
keywords = "CCN family, Fibrosis, Gene regulation, Malignancy, Matricellular protein",
author = "Satoshi Kubota and Masaharu Takigawa",
year = "2014",
doi = "10.1042/CS20140264",
language = "English",
volume = "128",
pages = "181--196",
journal = "Clinical Science",
issn = "0143-5221",
publisher = "Portland Press Ltd.",
number = "3",

}

TY - JOUR

T1 - Cellular and molecular actions of CCN2/CTGF and its role under physiological and pathological conditions

AU - Kubota, Satoshi

AU - Takigawa, Masaharu

PY - 2014

Y1 - 2014

N2 - CCN family protein 2 (CCN2), also widely known as connective tissue growth factor (CTGF), is one of the founding members of the CCN family of matricellular proteins. Extensive investigation on CCN2 over decades has revealed the novel molecular action and functional properties of this unique signalling modulator. By its interaction with multiple molecular counterparts, CCN2 yields highly diverse and context-dependent biological outcomes in a variety of microenvironments. Nowadays, CCN2 is recognized to conduct the harmonized development of relevant tissues, such as cartilage and bone, in the skeletal system, by manipulating extracellular signalling molecules involved therein by acting as a hub through a web. However, on the other hand, CCN2 occasionally plays profound roles in major human biological disorders, including fibrosis and malignancies in major organs and tissues, by modulating the actions of key molecules involved in these clinical entities. In this review, the physiological and pathological roles of this unique protein are comprehensively summarized from a molecular network-based viewpoint of CCN2 functionalities.

AB - CCN family protein 2 (CCN2), also widely known as connective tissue growth factor (CTGF), is one of the founding members of the CCN family of matricellular proteins. Extensive investigation on CCN2 over decades has revealed the novel molecular action and functional properties of this unique signalling modulator. By its interaction with multiple molecular counterparts, CCN2 yields highly diverse and context-dependent biological outcomes in a variety of microenvironments. Nowadays, CCN2 is recognized to conduct the harmonized development of relevant tissues, such as cartilage and bone, in the skeletal system, by manipulating extracellular signalling molecules involved therein by acting as a hub through a web. However, on the other hand, CCN2 occasionally plays profound roles in major human biological disorders, including fibrosis and malignancies in major organs and tissues, by modulating the actions of key molecules involved in these clinical entities. In this review, the physiological and pathological roles of this unique protein are comprehensively summarized from a molecular network-based viewpoint of CCN2 functionalities.

KW - CCN family

KW - Fibrosis

KW - Gene regulation

KW - Malignancy

KW - Matricellular protein

UR - http://www.scopus.com/inward/record.url?scp=84921732374&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921732374&partnerID=8YFLogxK

U2 - 10.1042/CS20140264

DO - 10.1042/CS20140264

M3 - Article

C2 - 25294165

AN - SCOPUS:84921732374

VL - 128

SP - 181

EP - 196

JO - Clinical Science

JF - Clinical Science

SN - 0143-5221

IS - 3

ER -