Cell Therapy for Parkinson’s Disease

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Cell therapy for Parkinson’s disease (PD) began in 1979 with the transplantation of fetal rat dopamine-containing neurons that improved motor abnormalities in the PD rat model with good survival of grafts and axonal outgrowth. Thirty years have passed since the 2 clinical trials using cell transplantation for PD patients were first reported. Recently, cell therapy is expected to develop as a realistic treatment option for PD patients owing to the advancement of biotechnology represented by pluripotent stem cells. Medication using levodopa, surgery including deep brain stimulation, and rehabilitation have all been established as current therapeutic strategies. Strong therapeutic effects have been demonstrated by these treatment methods, but they have been unable to stop the progression of the disease. Fortunately, cell therapy might be a key for true neurorestoration. This review article describes the historical development of cell therapy for PD, the current status of cell therapy, and the future direction of this treatment method.

Original languageEnglish
Pages (from-to)1551-1559
Number of pages9
JournalCell Transplantation
Volume26
Issue number9
DOIs
Publication statusPublished - Sep 1 2017

Fingerprint

Cell- and Tissue-Based Therapy
Parkinson Disease
Historical Tissue Therapy
Rats
Pluripotent Stem Cells
Deep Brain Stimulation
Dopaminergic Neurons
Cell Transplantation
Levodopa
Therapeutic Uses
Graft Survival
Therapeutics
Biotechnology
Disease Progression
Stem cells
Grafts
Patient rehabilitation
Rehabilitation
Surgery
Transplantation

Keywords

  • cell therapy
  • dopaminergic neuron
  • ES cells
  • iPSCs
  • transplantation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cell Biology
  • Transplantation

Cite this

Cell Therapy for Parkinson’s Disease. / Yasuhara, Takao; Kameda, Masahiro; Sasaki, Tatsuya; Tajiri, Naoki; Date, Isao.

In: Cell Transplantation, Vol. 26, No. 9, 01.09.2017, p. 1551-1559.

Research output: Contribution to journalReview article

@article{46790727ff9e4a349e40e5c82ea30db6,
title = "Cell Therapy for Parkinson’s Disease",
abstract = "Cell therapy for Parkinson’s disease (PD) began in 1979 with the transplantation of fetal rat dopamine-containing neurons that improved motor abnormalities in the PD rat model with good survival of grafts and axonal outgrowth. Thirty years have passed since the 2 clinical trials using cell transplantation for PD patients were first reported. Recently, cell therapy is expected to develop as a realistic treatment option for PD patients owing to the advancement of biotechnology represented by pluripotent stem cells. Medication using levodopa, surgery including deep brain stimulation, and rehabilitation have all been established as current therapeutic strategies. Strong therapeutic effects have been demonstrated by these treatment methods, but they have been unable to stop the progression of the disease. Fortunately, cell therapy might be a key for true neurorestoration. This review article describes the historical development of cell therapy for PD, the current status of cell therapy, and the future direction of this treatment method.",
keywords = "cell therapy, dopaminergic neuron, ES cells, iPSCs, transplantation",
author = "Takao Yasuhara and Masahiro Kameda and Tatsuya Sasaki and Naoki Tajiri and Isao Date",
year = "2017",
month = "9",
day = "1",
doi = "10.1177/0963689717735411",
language = "English",
volume = "26",
pages = "1551--1559",
journal = "Cell Transplantation",
issn = "0963-6897",
publisher = "Cognizant Communication Corporation",
number = "9",

}

TY - JOUR

T1 - Cell Therapy for Parkinson’s Disease

AU - Yasuhara, Takao

AU - Kameda, Masahiro

AU - Sasaki, Tatsuya

AU - Tajiri, Naoki

AU - Date, Isao

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Cell therapy for Parkinson’s disease (PD) began in 1979 with the transplantation of fetal rat dopamine-containing neurons that improved motor abnormalities in the PD rat model with good survival of grafts and axonal outgrowth. Thirty years have passed since the 2 clinical trials using cell transplantation for PD patients were first reported. Recently, cell therapy is expected to develop as a realistic treatment option for PD patients owing to the advancement of biotechnology represented by pluripotent stem cells. Medication using levodopa, surgery including deep brain stimulation, and rehabilitation have all been established as current therapeutic strategies. Strong therapeutic effects have been demonstrated by these treatment methods, but they have been unable to stop the progression of the disease. Fortunately, cell therapy might be a key for true neurorestoration. This review article describes the historical development of cell therapy for PD, the current status of cell therapy, and the future direction of this treatment method.

AB - Cell therapy for Parkinson’s disease (PD) began in 1979 with the transplantation of fetal rat dopamine-containing neurons that improved motor abnormalities in the PD rat model with good survival of grafts and axonal outgrowth. Thirty years have passed since the 2 clinical trials using cell transplantation for PD patients were first reported. Recently, cell therapy is expected to develop as a realistic treatment option for PD patients owing to the advancement of biotechnology represented by pluripotent stem cells. Medication using levodopa, surgery including deep brain stimulation, and rehabilitation have all been established as current therapeutic strategies. Strong therapeutic effects have been demonstrated by these treatment methods, but they have been unable to stop the progression of the disease. Fortunately, cell therapy might be a key for true neurorestoration. This review article describes the historical development of cell therapy for PD, the current status of cell therapy, and the future direction of this treatment method.

KW - cell therapy

KW - dopaminergic neuron

KW - ES cells

KW - iPSCs

KW - transplantation

UR - http://www.scopus.com/inward/record.url?scp=85034045957&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85034045957&partnerID=8YFLogxK

U2 - 10.1177/0963689717735411

DO - 10.1177/0963689717735411

M3 - Review article

C2 - 29113472

AN - SCOPUS:85034045957

VL - 26

SP - 1551

EP - 1559

JO - Cell Transplantation

JF - Cell Transplantation

SN - 0963-6897

IS - 9

ER -