Cell proliferation and tissue compatibility of organic-inorganic hybrid materials

Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Sol-gel preparation of few organic-inorganic hybrids have been reviewed briefly as well as their behaviors under contact with blood plasma using a simulated body fluid (SBF) of the Kokubo recipe mimicking plasma. The starting resources of the hybrids included not only such silanes as poly(dimethylsiloxane) (PDMS), 3-glycidoxypropyltrimethoxysilane (GPTMS), tetraethoxysilane (TEOS), and titanium tetra-isopropoxide, but gelatin and chitosan. Apatite deposition in SBF was examined for the solid hybrids or membranes, and cell compatibility was assessed on proliferating osteoblastic cells (MC3T3E1, MG63). In addition, 3-dimensional interconnected pore structure was established for those hybrids, for which the possibility for scaffold and bioreactor applications was examined in terms of cell proliferation of human hepatocytes or keratinocytes. Gelatin-GPTMS and PDMS-TEOS scaffolds were implanted in brain defects to see no inflammation. Nerve cell tissue regeneration was observed, which was enhanced by the impregnation of growth factors, like bFGF and VEGF. With observing those empirical data, the silane based organic-inorganic hybrids have been considered very promising for tissue regeneration scaffolds.

Original languageEnglish
Pages (from-to)167-180
Number of pages14
JournalKey Engineering Materials
Volume377
DOIs
Publication statusPublished - 2008

Fingerprint

Silanes
Tissue regeneration
Body fluids
Hybrid materials
Cell proliferation
Polydimethylsiloxane
Gelatin
Scaffolds
Tissue
Plasmas
Apatites
Apatite
Chitosan
Polymers
Scaffolds (biology)
Pore structure
Titanium
Bioreactors
Impregnation
Vascular Endothelial Growth Factor A

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemical Engineering (miscellaneous)

Cite this

Cell proliferation and tissue compatibility of organic-inorganic hybrid materials. / Tsuru, Kanji; Hayakawa, Satoshi; Osaka, Akiyoshi.

In: Key Engineering Materials, Vol. 377, 2008, p. 167-180.

Research output: Contribution to journalArticle

@article{e5730c7dd0a24df091b689c5723356c6,
title = "Cell proliferation and tissue compatibility of organic-inorganic hybrid materials",
abstract = "Sol-gel preparation of few organic-inorganic hybrids have been reviewed briefly as well as their behaviors under contact with blood plasma using a simulated body fluid (SBF) of the Kokubo recipe mimicking plasma. The starting resources of the hybrids included not only such silanes as poly(dimethylsiloxane) (PDMS), 3-glycidoxypropyltrimethoxysilane (GPTMS), tetraethoxysilane (TEOS), and titanium tetra-isopropoxide, but gelatin and chitosan. Apatite deposition in SBF was examined for the solid hybrids or membranes, and cell compatibility was assessed on proliferating osteoblastic cells (MC3T3E1, MG63). In addition, 3-dimensional interconnected pore structure was established for those hybrids, for which the possibility for scaffold and bioreactor applications was examined in terms of cell proliferation of human hepatocytes or keratinocytes. Gelatin-GPTMS and PDMS-TEOS scaffolds were implanted in brain defects to see no inflammation. Nerve cell tissue regeneration was observed, which was enhanced by the impregnation of growth factors, like bFGF and VEGF. With observing those empirical data, the silane based organic-inorganic hybrids have been considered very promising for tissue regeneration scaffolds.",
author = "Kanji Tsuru and Satoshi Hayakawa and Akiyoshi Osaka",
year = "2008",
doi = "10.4028/0-87849-395-6.167",
language = "English",
volume = "377",
pages = "167--180",
journal = "Key Engineering Materials",
issn = "1013-9826",
publisher = "Trans Tech Publications",

}

TY - JOUR

T1 - Cell proliferation and tissue compatibility of organic-inorganic hybrid materials

AU - Tsuru, Kanji

AU - Hayakawa, Satoshi

AU - Osaka, Akiyoshi

PY - 2008

Y1 - 2008

N2 - Sol-gel preparation of few organic-inorganic hybrids have been reviewed briefly as well as their behaviors under contact with blood plasma using a simulated body fluid (SBF) of the Kokubo recipe mimicking plasma. The starting resources of the hybrids included not only such silanes as poly(dimethylsiloxane) (PDMS), 3-glycidoxypropyltrimethoxysilane (GPTMS), tetraethoxysilane (TEOS), and titanium tetra-isopropoxide, but gelatin and chitosan. Apatite deposition in SBF was examined for the solid hybrids or membranes, and cell compatibility was assessed on proliferating osteoblastic cells (MC3T3E1, MG63). In addition, 3-dimensional interconnected pore structure was established for those hybrids, for which the possibility for scaffold and bioreactor applications was examined in terms of cell proliferation of human hepatocytes or keratinocytes. Gelatin-GPTMS and PDMS-TEOS scaffolds were implanted in brain defects to see no inflammation. Nerve cell tissue regeneration was observed, which was enhanced by the impregnation of growth factors, like bFGF and VEGF. With observing those empirical data, the silane based organic-inorganic hybrids have been considered very promising for tissue regeneration scaffolds.

AB - Sol-gel preparation of few organic-inorganic hybrids have been reviewed briefly as well as their behaviors under contact with blood plasma using a simulated body fluid (SBF) of the Kokubo recipe mimicking plasma. The starting resources of the hybrids included not only such silanes as poly(dimethylsiloxane) (PDMS), 3-glycidoxypropyltrimethoxysilane (GPTMS), tetraethoxysilane (TEOS), and titanium tetra-isopropoxide, but gelatin and chitosan. Apatite deposition in SBF was examined for the solid hybrids or membranes, and cell compatibility was assessed on proliferating osteoblastic cells (MC3T3E1, MG63). In addition, 3-dimensional interconnected pore structure was established for those hybrids, for which the possibility for scaffold and bioreactor applications was examined in terms of cell proliferation of human hepatocytes or keratinocytes. Gelatin-GPTMS and PDMS-TEOS scaffolds were implanted in brain defects to see no inflammation. Nerve cell tissue regeneration was observed, which was enhanced by the impregnation of growth factors, like bFGF and VEGF. With observing those empirical data, the silane based organic-inorganic hybrids have been considered very promising for tissue regeneration scaffolds.

UR - http://www.scopus.com/inward/record.url?scp=43949085061&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=43949085061&partnerID=8YFLogxK

U2 - 10.4028/0-87849-395-6.167

DO - 10.4028/0-87849-395-6.167

M3 - Article

AN - SCOPUS:43949085061

VL - 377

SP - 167

EP - 180

JO - Key Engineering Materials

JF - Key Engineering Materials

SN - 1013-9826

ER -