Cell Differentiation of MDPC-23 Cells Derived from Mouse Papilla Tissues

Kazuo Ichikawa, Hitoshi Nagatsuka, Hidetsugu Tsujigiwa, Noriyuki Nagai

Research output: Contribution to journalArticlepeer-review


For the purpose of developing a hybrid type dentin with periodontal membrane implant, we conducted in vitro and in vivo experiments using a mouse dental papilla-derived cell line MDPC-23 to study anatomical and functional differentiation. Our results show that MDPC-23 cells possess dentin-inducing characteristics and differentiate into odontoblast-like cells extending cytoplasmic projection unilaterally.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalJournal of Hard Tissue Biology
Issue number3
Publication statusPublished - Jan 2004


  • MDPC-23
  • cell differentiation
  • dentin sialophosphoprotein
  • odonotoblast
  • regeneration

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry
  • Biomaterials
  • Orthopedics and Sports Medicine
  • Dentistry(all)
  • Cell Biology


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