Cell differentiation inducers derived from thalidomide

Tomomi Noguchi, Hiroyuki Miyachi, Ryohei Katayama, Mikihiko Naito, Yuichi Hashimoto

Research output: Contribution to journalArticle

13 Citations (Scopus)


5-Hydroxy- and 4-amino-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione (5HPP-33 and 4APP-33, respectively) have been shown to possess cell differentiation-inducing activity toward human leukemia cell line HL-60.

Original languageEnglish
Pages (from-to)3212-3215
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number13
Publication statusPublished - Jul 1 2005


  • Cell differentiation
  • HL-60
  • Phenylphthalimide
  • Thalidomide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Noguchi, T., Miyachi, H., Katayama, R., Naito, M., & Hashimoto, Y. (2005). Cell differentiation inducers derived from thalidomide. Bioorganic and Medicinal Chemistry Letters, 15(13), 3212-3215. https://doi.org/10.1016/j.bmcl.2005.05.005