Cell cycle abnormality in metabolic syndrome and nuclear receptors as an emerging therapeutic target

Atsuko Nakatsuka, Jun Wada, Hirofumi Makino

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In recent years, many researchers have emphasized the importance of metabolic syndrome based on its increasing prevalence and its adverse prognosis due to associated chronic vascular complications. Upstream of a cluster of metabolic and vascular disorders is the accumulation of visceral adipose tis-sue, which plays a central role in the pathophysiology. In the accumulation of adipose tissues, cell cycle regulation is tightly linked to cellular processes such as proliferation, hypertrophy and apopto-sis. In addition, various cell cycle abnormalities have also been observed in other tissues, such as kidneys and the cardiovascular system, and they are critically involved in the progression of disease. Here, we discuss cell cycle abnormalities in metabolic syndrome in various tissues. Furthermore, we describe the role of nuclear receptors in cell growth and survival, and glucose and lipid metabolism in the whole body. Therapeutic strategies for modulating various cell cycles in metabolic disorders by targeting nuclear receptors may overcome obesity and its chronic vascular complications in the future

Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalActa medica Okayama
Volume67
Issue number3
Publication statusPublished - 2013

Keywords

  • Cell cycle
  • Diabetic nephropathy
  • Metabolic syndrome
  • Nuclear receptor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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