Cell-based biological pacemakers

Progress and problems

Research output: Contribution to journalReview article

Abstract

The number of permanent pacemaker implantations has been increasing due to the aging of populations worldwide and the increase in the numbers of patients with heart diseases. Commercially available mechanical pacemakers are very useful but still have some problems including short battery life, a risk of infection, the absence of physiological autonomic responsiveness, metal allergy, and electronic interference. A biological pacemaker may resolve these problems and regenerate the cardiac pacemaker. Cell-based therapy and gene therapy have been addressed with the goal of solving the challenges of biological pacemaker. However, the clinical application of a biological pacemaker has not yet been realized. Here we discuss the types of cells that can be used for a biological pacemaker and the problems that remain regarding the clinical applications of cell-based therapy.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalActa Medica Okayama
Volume72
Issue number1
Publication statusPublished - Jan 1 2018

Fingerprint

Biological Clocks
Pacemakers
Cell- and Tissue-Based Therapy
Genetic Therapy
Heart Diseases
Hypersensitivity
Allergies
Metals
Gene therapy
Infection
Population
Aging of materials

Keywords

  • Biological pacemaker
  • Cardiomyocytes
  • Cell therapy
  • Hyperpolarization activated cyclic nucleotide gated potassium channel 4
  • Pluripotent stem cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Cell-based biological pacemakers : Progress and problems. / Saito, Yukihiro; Nakamura, Kazufumi; Itoh, Hiroshi.

In: Acta Medica Okayama, Vol. 72, No. 1, 01.01.2018, p. 1-7.

Research output: Contribution to journalReview article

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