Cefodizime in complicated urinary tract infections

Masaya Tsugawa, Daisuke Yamada, Yoshitsugu Nasu, Mikio Kishi, Akihiro Mizuno, Hiromi Kumon, Hiroyuki Ohmori, Katsuichi Nanba, Yasuhiro Katayama, Katsuyoshi Kondo, Teruaki Akaeda, Hitoshi Takamoto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We studied the antibacterial activity and clinical efficacy of cefodizime, a new cephem antibiotic. 1. The antibacterial activity of cefodizime was weak against P. aeruginosa, but excellent against E. coli, K. pnessmoniae, P. mirabilis and S. marcescens. Against E. faecalis and S. marcescens the drug was superior to CPZ and LMOX, but against P. aeruginosa it was inferior to CTX, CPZ and LMOX. 2. Thirty-one patients with complicated urinary tract infection were treated with cefodizime. According to the criteria of the UTI Committee, the overall clinical efficacy rate was 70.4%(19/27). 3. As for side-effects, diarrhea was observed in 1 patient (3%), and abnormal laboratory findings were observed in 3 patients, showing transient elevation of GOT/GPT or anemia.

Original languageEnglish
Pages (from-to)677-690
Number of pages14
JournalCHEMOTHERAPY
Volume36
DOIs
Publication statusPublished - Jan 1 1988

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology
  • Drug Discovery
  • Oncology

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  • Cite this

    Tsugawa, M., Yamada, D., Nasu, Y., Kishi, M., Mizuno, A., Kumon, H., Ohmori, H., Nanba, K., Katayama, Y., Kondo, K., Akaeda, T., & Takamoto, H. (1988). Cefodizime in complicated urinary tract infections. CHEMOTHERAPY, 36, 677-690. https://doi.org/10.11250/chemotherapy1953.36.Supplement5_677