CDH13 polymorphisms are associated with adiponectin levels and metabolic syndrome traits independently of visceral fat mass

Aya Kitamoto, Takuya Kitamoto, Takahiro Nakamura, Tomoaki Matsuo, Yoshio Nakata, Hideyuki Hyogo, Hidenori Ochi, Seika Kamohara, Nobuyuki Miyatake, Kazuaki Kotani, Ikuo Mineo, Jun Wada, Yuji Ogawa, Masato Yoneda, Atsushi Nakajima, Tohru Funahashi, Shigeru Miyazaki, Katsuto Tokunaga, Hiroaki Masuzaki, Takato UenoKazuaki Chayama, Kazuyuki Hamaguchi, Kentaro Yamada, Toshiaki Hanafusa, Shinichi Oikawa, Toshiie Sakata, Kiyoji Tanaka, Yuji Matsuzawa, Kikuko Hotta

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Aim: Visceral fat accumulation contributes to the development of metabolic syndrome. As visceral fat accumulation increases, adiponectin levels decrease; therefore, adiponectin provides a link between visceral fat accumulation and metabolic disorders. Genome-wide association studies (GWASs) have identified genetic variations in the cadherin 13 (CDH13) gene that are associated with adiponectin levels. Methods: We investigated whether single nucleotide polymorphisms (SNPs) in CDH13 was associated with adiponectin levels and metabolic syndrome traits independent of the visceral fat area (VFA), as measured using computed tomography (CT) in 945 Japanese individuals. Results: We found that three CDH13 SNPs reported by recent GWASs (i.e., rs3865188, rs4783244, and rs12051272) were significantly associated with higher adiponectin levels (P<1×10-14), even after adjustment for VFA. However, these adiponectin-inducing alleles of CDH13 SNPs were significantly associated with traits consistent with deteriorating metabolic symptoms, such as higher fasting insulin, homeostasis model assessment–insulin resistance (HOMA-IR) scores, and triglycerides and lower highdensity lipoprotein (HDL)-cholesterol levels, similar to increasing VFA and decreasing adiponectin levels. Conclusion: These results suggested that CDH13 SNPs cause an adiponectin-resistant status to compensate for increasing adiponectin levels and could result in the deterioration of metabolic syndrome traits.

Original languageEnglish
Pages (from-to)309-319
Number of pages11
JournalJournal of atherosclerosis and thrombosis
Volume23
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'CDH13 polymorphisms are associated with adiponectin levels and metabolic syndrome traits independently of visceral fat mass'. Together they form a unique fingerprint.

  • Cite this

    Kitamoto, A., Kitamoto, T., Nakamura, T., Matsuo, T., Nakata, Y., Hyogo, H., Ochi, H., Kamohara, S., Miyatake, N., Kotani, K., Mineo, I., Wada, J., Ogawa, Y., Yoneda, M., Nakajima, A., Funahashi, T., Miyazaki, S., Tokunaga, K., Masuzaki, H., ... Hotta, K. (2016). CDH13 polymorphisms are associated with adiponectin levels and metabolic syndrome traits independently of visceral fat mass. Journal of atherosclerosis and thrombosis, 23(3), 309-319. https://doi.org/10.5551/jat.31567