Cdc37 as a Co-chaperone to Hsp90

Thomas L. Prince, Benjamin J. Lang, Yuka Okusya, Takanori Eguchi, Stuart K. Calderwood

Research output: Chapter in Book/Report/Conference proceedingChapter


The co-chaperone p50/Cdc37 is an important partner for Hsp90, assisting in molecular chaperone activities, particularly with regard to the regulation of protein kinases. Analysis of the structure of Hsp90-Cdc37-kinase complexes demonstrates the way in which Cdc37 interacts with and controls the folding of a large proportion of intracellular protein kinases. This co-chaperone thus stands at the hub of a multitude of intracellular signaling networks. Indeed, the influence of Cdc37 reaches beyond the housekeeping pathways of protein folding into the regulation of a wide range of cellular processes. This co-chaperone has attracted attention as a potential intermediate in carcinogenesis. Cdc37 is an attractive potential target in cancer due to (1) high expression in a number of tumor types and (2) control of multiple signaling pathways. These properties indicate (3) a potential for selectivity due to its elevated expression in malignant cells and (4) robustness, as the co-chaperone may control multiple growth signaling pathways and thus be less prone to evolution of resistance than less versatile oncoproteins. Cdc37 may also be involved in other aspects of pathophysiology and has been shown to be secreted in exosomes. Protein aggregation disorders have been linked to age-related declines in molecular chaperones and co-chaperones. Cdc37 also appears to be a potential agent in longevity due to its links to protein folding and autophagy, and it will be informative to study the role of Cdc37 maintenance/decline in aging organisms.

Original languageEnglish
Title of host publicationSubcellular Biochemistry
PublisherSpringer Science and Business Media B.V.
Number of pages18
Publication statusPublished - 2023

Publication series

NameSubcellular Biochemistry
ISSN (Print)0306-0225


  • Autophagy
  • Cancer
  • Cdc37
  • Chaperone
  • Hsp90
  • Kinase
  • Neurodegenerative

ASJC Scopus subject areas

  • Medicine(all)


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