TY - JOUR
T1 - CD95 ligand is expressed in Reed-Sternberg cells of Hodgkin's disease
AU - Sakuma, Isao
AU - Yoshino, Tadashi
AU - Omonishi, Kunihiro
AU - Nishiuchi, Ritsuo
AU - Teramoto, Norihiro
AU - Yanai, Hiroyuki
AU - Kawahara, Kunimitsu
AU - Kubonishi, Ichiro
AU - Matsuo, Yoshinobu
AU - Akagi, Tadaatsu
PY - 1999
Y1 - 1999
N2 - Reed-Sternberg (RS) cells and their mononuclear variants, Hodgkin's (H) cells, are considered to be the neoplastic cells of Hodgkin's disease (HD). The cellular origin of H-RS cells remains the subject of considerable controversy, although most recent papers have claimed that H-RS cells are of B cell origin. Recently, however, it has been reported that some H-RS cells express granzyme B, as observed in cytotoxic T cells and/or natural killer cells, which also express CD95 ligand (FasL/APO-1L). In the present study, the expression of CD95L and granzyme B in H-RS cells of HD was investigated. CD95L was detected in H-RS cells in five of nine HD cases (one case of lymphocyte-rich classical HD, two of these cases of nodular sclerosis type, and two of four cases of mixed cellularity type). All three examined HD cell lines expressed CD95L in the cytoplasm, although cell surface expression was seen only in L428 cells. Three HD cases expressed both CD95L and granzyme B. It was concluded that CD95L is frequently expressed in H-RS cells, which is one of their notable characteristics; albeit it seems to be irrespective of cell lineage.
AB - Reed-Sternberg (RS) cells and their mononuclear variants, Hodgkin's (H) cells, are considered to be the neoplastic cells of Hodgkin's disease (HD). The cellular origin of H-RS cells remains the subject of considerable controversy, although most recent papers have claimed that H-RS cells are of B cell origin. Recently, however, it has been reported that some H-RS cells express granzyme B, as observed in cytotoxic T cells and/or natural killer cells, which also express CD95 ligand (FasL/APO-1L). In the present study, the expression of CD95L and granzyme B in H-RS cells of HD was investigated. CD95L was detected in H-RS cells in five of nine HD cases (one case of lymphocyte-rich classical HD, two of these cases of nodular sclerosis type, and two of four cases of mixed cellularity type). All three examined HD cell lines expressed CD95L in the cytoplasm, although cell surface expression was seen only in L428 cells. Three HD cases expressed both CD95L and granzyme B. It was concluded that CD95L is frequently expressed in H-RS cells, which is one of their notable characteristics; albeit it seems to be irrespective of cell lineage.
KW - CD95 ligand
KW - Granzyme B
KW - Hodgkin's disease
KW - Reed-Sternberg cell
KW - T cell intracellular antigen 1
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U2 - 10.1046/j.1440-1827.1999.00830.x
DO - 10.1046/j.1440-1827.1999.00830.x
M3 - Article
C2 - 10355962
AN - SCOPUS:0033003298
VL - 49
SP - 103
EP - 109
JO - Acta Pathologica Japonica
JF - Acta Pathologica Japonica
SN - 1320-5463
IS - 2
ER -