CD4+ cells are indispensable for ulcer development in murine cutaneous leishmaniasis

Masaki Terabe, Takashi Kuramochi, Mamoru Ito, Toshimitsu Hatabu, Chizu Sanjoba, Kwang Poo Chang, Takashi Onodera, Yoshitsugu Matsumoto

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

One of the most characteristic clinical features in cutaneous leishmaniasis is the development of nodules followed by ulcerations at the site of infection. Leishmania amazonensis-infected mice show similar ulcerative lesions. Leishmania-infected severe combined immunodeficiency (SCID) mice, however, have been shown to develop nonulcerative nodules. In the present study, the roles of T cells in ulceration were examined using SCID mice in cell reconstitution experiments. After development of nonulcerative nodules, SCID mice were inoculated with splenocytes from either Leishmania-infected or naive immunocompetent mice, resulting in ulceration in all mice. When naive splenocytes were depleted of CD4+, CD8+, or B220+ cell populations and the remaining cells were injected into Leishmania- infected SCID mice after the development of nodules, only SCID mice inoculated with splenocytes depleted of CD4+ cells did not show ulceration. The evidence obtained in this study clearly shows that the CD4+ cell population is indispensable for ulceration in leishmaniasis lesions of SCID mice.

Original languageEnglish
Pages (from-to)4574-4577
Number of pages4
JournalInfection and Immunity
Volume68
Issue number8
DOIs
Publication statusPublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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