CD44 exon v6 is not implicated in the progression and metastasis of endometrial cancer

Keizo Tokumo, Junichi Kodama, Noriko Seki, Yasunari Miyagi, Mitsuo Yoshinouchi, Takafumi Kudo

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We examined the presence of mRNA for CD44v6 and assessed the association with clinicopathological features in 42 patients with endometrial cancer by RT-PCR and subsequent Southern blot hybridization with oligonucleotide probe specific for v6. The standard form of CD44 was expressed in all specimens and 20 out of 42 endometrial cancers expressed an isoform containing exon v6 in combination with other variant exons. However, there was no correlation between the expression of CD44v6 and any clinicopathological factors. These findings suggested that the expression of CD44v6 is not implicated in the progression and metastasis of endometrial cancer.

Original languageEnglish
Pages (from-to)221-225
Number of pages5
JournalCancer Letters
Volume125
Issue number1-2
DOIs
Publication statusPublished - Mar 13 1998

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Endometrial Neoplasms
Exons
Neoplasm Metastasis
Oligonucleotide Probes
Southern Blotting
Protein Isoforms
Polymerase Chain Reaction
Messenger RNA

Keywords

  • CD44v6
  • Endometrial cancer
  • Metastasis

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Tokumo, K., Kodama, J., Seki, N., Miyagi, Y., Yoshinouchi, M., & Kudo, T. (1998). CD44 exon v6 is not implicated in the progression and metastasis of endometrial cancer. Cancer Letters, 125(1-2), 221-225. https://doi.org/10.1016/S0304-3835(97)00517-X

CD44 exon v6 is not implicated in the progression and metastasis of endometrial cancer. / Tokumo, Keizo; Kodama, Junichi; Seki, Noriko; Miyagi, Yasunari; Yoshinouchi, Mitsuo; Kudo, Takafumi.

In: Cancer Letters, Vol. 125, No. 1-2, 13.03.1998, p. 221-225.

Research output: Contribution to journalArticle

Tokumo, K, Kodama, J, Seki, N, Miyagi, Y, Yoshinouchi, M & Kudo, T 1998, 'CD44 exon v6 is not implicated in the progression and metastasis of endometrial cancer', Cancer Letters, vol. 125, no. 1-2, pp. 221-225. https://doi.org/10.1016/S0304-3835(97)00517-X
Tokumo, Keizo ; Kodama, Junichi ; Seki, Noriko ; Miyagi, Yasunari ; Yoshinouchi, Mitsuo ; Kudo, Takafumi. / CD44 exon v6 is not implicated in the progression and metastasis of endometrial cancer. In: Cancer Letters. 1998 ; Vol. 125, No. 1-2. pp. 221-225.
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