CD34+-selected autologous peripheral blood stem cell transplantation conditioned with total body irradiation for malignant lymphoma: increased risk of infectious complications

Satoko Maeda, Yoshitoyo Kagami, Michinori Ogura, Hirofumi Taji, Ritsuro Suzuki, Eisei Kondo, Shouji Asakura, Takahiro Takeuchi, Kazuhisa Miura, Manabu Ando, Shigeo Nakamura, Tatsuya Ito, Tomohiro Kinoshita, Ryuzo Ueda, Yasuo Morishima

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Although high-dose chemotherapy with autologous peripheral blood stem cell transplantation (autoPBSCT) has been shown or confirmed to be an effective treatment for high-risk and relapsed non-Hodgkin's lymphoma (NHL), relapse after autoPBSCT remains a serious problem. In a clinical trial to overcome relapse, we adopted a treatment plan in which PBSCs purified in vitro to CD34+ cells to deplete tumor cells (CD34+ autoPBSCT), total body irradiation (TBI) of 1200 cGy, and melphalan, 180 mg/m2, were used as a preconditioning regimen. Eighteen patients with relapsed or high-risk NHL participated in the study. This study compared the incidence of complications following CD34+ autoPBSCT preconditioned with the TBI regimen (n = 10): the TBI group; CD34+ autoPBSCT with the non-TBI regimen (n = 8): the non-TBI group; and unselected autoPBSCT with the non-TBI regimen (n = 19): the unselected autoPBSCT control group. After day 30 posttransplantation, 6 of 10 patients treated with the TBI regimen developed 11 infectious complications in total, compared with only 1 of 8 patients treated with the non-TBI regimen and 4 of 19 patients given unselected autoPBSCT. Two fatal complications occurred in the TBI group, but none occurred in the other 2 groups. The CD4+ lymphocyte count at 1 month posttransplantation was significantly lower in the TBI group than in the unselected autoPBSCT group. These findings suggest that the addition of TBI to the preconditioning regimen for CD34+ autoPBSCT is associated with an increased incidence of severe infectious complications after transplantation.

Original languageEnglish
Pages (from-to)214-221
Number of pages8
JournalInternational Journal of Hematology
Volume74
Issue number2
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Peripheral Blood Stem Cell Transplantation
Whole-Body Irradiation
Lymphoma
Non-Hodgkin's Lymphoma
Recurrence
Melphalan
CD4 Lymphocyte Count
Cohort Studies
Transplantation
Clinical Trials

Keywords

  • Autologous peripheral blood stem cell transplantation
  • CD34 cell
  • Lymphoma
  • Opportunistic infection
  • Total body irradiation

ASJC Scopus subject areas

  • Hematology

Cite this

CD34+-selected autologous peripheral blood stem cell transplantation conditioned with total body irradiation for malignant lymphoma : increased risk of infectious complications. / Maeda, Satoko; Kagami, Yoshitoyo; Ogura, Michinori; Taji, Hirofumi; Suzuki, Ritsuro; Kondo, Eisei; Asakura, Shouji; Takeuchi, Takahiro; Miura, Kazuhisa; Ando, Manabu; Nakamura, Shigeo; Ito, Tatsuya; Kinoshita, Tomohiro; Ueda, Ryuzo; Morishima, Yasuo.

In: International Journal of Hematology, Vol. 74, No. 2, 2001, p. 214-221.

Research output: Contribution to journalArticle

Maeda, S, Kagami, Y, Ogura, M, Taji, H, Suzuki, R, Kondo, E, Asakura, S, Takeuchi, T, Miura, K, Ando, M, Nakamura, S, Ito, T, Kinoshita, T, Ueda, R & Morishima, Y 2001, 'CD34+-selected autologous peripheral blood stem cell transplantation conditioned with total body irradiation for malignant lymphoma: increased risk of infectious complications', International Journal of Hematology, vol. 74, no. 2, pp. 214-221.
Maeda, Satoko ; Kagami, Yoshitoyo ; Ogura, Michinori ; Taji, Hirofumi ; Suzuki, Ritsuro ; Kondo, Eisei ; Asakura, Shouji ; Takeuchi, Takahiro ; Miura, Kazuhisa ; Ando, Manabu ; Nakamura, Shigeo ; Ito, Tatsuya ; Kinoshita, Tomohiro ; Ueda, Ryuzo ; Morishima, Yasuo. / CD34+-selected autologous peripheral blood stem cell transplantation conditioned with total body irradiation for malignant lymphoma : increased risk of infectious complications. In: International Journal of Hematology. 2001 ; Vol. 74, No. 2. pp. 214-221.
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abstract = "Although high-dose chemotherapy with autologous peripheral blood stem cell transplantation (autoPBSCT) has been shown or confirmed to be an effective treatment for high-risk and relapsed non-Hodgkin's lymphoma (NHL), relapse after autoPBSCT remains a serious problem. In a clinical trial to overcome relapse, we adopted a treatment plan in which PBSCs purified in vitro to CD34+ cells to deplete tumor cells (CD34+ autoPBSCT), total body irradiation (TBI) of 1200 cGy, and melphalan, 180 mg/m2, were used as a preconditioning regimen. Eighteen patients with relapsed or high-risk NHL participated in the study. This study compared the incidence of complications following CD34+ autoPBSCT preconditioned with the TBI regimen (n = 10): the TBI group; CD34+ autoPBSCT with the non-TBI regimen (n = 8): the non-TBI group; and unselected autoPBSCT with the non-TBI regimen (n = 19): the unselected autoPBSCT control group. After day 30 posttransplantation, 6 of 10 patients treated with the TBI regimen developed 11 infectious complications in total, compared with only 1 of 8 patients treated with the non-TBI regimen and 4 of 19 patients given unselected autoPBSCT. Two fatal complications occurred in the TBI group, but none occurred in the other 2 groups. The CD4+ lymphocyte count at 1 month posttransplantation was significantly lower in the TBI group than in the unselected autoPBSCT group. These findings suggest that the addition of TBI to the preconditioning regimen for CD34+ autoPBSCT is associated with an increased incidence of severe infectious complications after transplantation.",
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AU - Taji, Hirofumi

AU - Suzuki, Ritsuro

AU - Kondo, Eisei

AU - Asakura, Shouji

AU - Takeuchi, Takahiro

AU - Miura, Kazuhisa

AU - Ando, Manabu

AU - Nakamura, Shigeo

AU - Ito, Tatsuya

AU - Kinoshita, Tomohiro

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AU - Morishima, Yasuo

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