CD204-Positive tumor-associated macrophages relate to malignant transformation of colorectal adenoma

Daiki Taniyama, Kiyomi Taniyama, Kazuya Kuraoka, Hideki Yamamoto, Junichi Zaitsu, Akihisa Saito, Naoya Sakamoto, Kazuhiro Sentani, Naohide Oue, Wataru Yasui

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Abstract

Background/Aim: Colorectal adenoma is well known as a precursor lesion of colorectal adenocarcinoma (ADC). We recently reported the significance of CD204 (+) tumor-associated macrophages (TAMs), a vital component of the tumor microenvironment, in the carcinoma development of gastric adenoma. The aim of the present study was to clarify the roles of TAM in the malignant transformation of colorectal adenoma. Materials and Methods: We immunohistochemically assessed the TAM number in 88 tubular or tubulovillous adenomas that were classified into L (low-grade adenomas) or H (high-grade adenomas). Results: Larger adenoma size, higher frequency of villous structure, loss of proliferation polarity, p53 expression, larger TAM numbers and larger microvessel density (MVD) were detected in Group H than in Group L adenomas. Positive relations were observed between TAM and MVD, proliferation polarity and the expression of p53. Conclusion: CD204 (+) TAM is a novel component in the malignant transformation of colorectal adenoma.

Original languageEnglish
Pages (from-to)2767-2775
Number of pages9
JournalAnticancer research
Volume39
Issue number6
DOIs
Publication statusPublished - Jan 1 2019
Externally publishedYes

Keywords

  • Adenoma-carcinoma sequence
  • CD204
  • Colorectal adenoma
  • Tumor-associated macrophages

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Taniyama, D., Taniyama, K., Kuraoka, K., Yamamoto, H., Zaitsu, J., Saito, A., Sakamoto, N., Sentani, K., Oue, N., & Yasui, W. (2019). CD204-Positive tumor-associated macrophages relate to malignant transformation of colorectal adenoma. Anticancer research, 39(6), 2767-2775. https://doi.org/10.21873/anticanres.13403