CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia

Hideki Muramatsu; Yoshiyuki Takahashi; Yoshie Shimoyama; Sayoko Doisaki; Nobuhiro Nishio; Yoshinori Ito; Asahito Hama; Akira Shimada; Hiroshi Yagasaki; Masafumi Ito; Seiji Kojima

doi:10.1007/s12185-011-0870-3

CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia

Hideki Muramatsu, Yoshiyuki Takahashi, Yoshie Shimoyama, Sayoko Doisaki, Nobuhiro Nishio, Yoshinori Ito, Asahito Hama, Akira Shimada, Hiroshi Yagasaki, Masafumi Ito, Seiji Kojima

University Hospital

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV-PTLD) is a life-threatening complication following allogeneic hematopoietic stem cell transplantation (HSCT). Monitoring of EBV DNA in high-risk patients with subsequent pre-emptive rituximab treatment is highly effective, and can prevent EBV-associated disease following HSCT. Here, we report a 10-year-old girl with aplastic anemia who developed CD20 negative EBV-PTLD after unrelated bone marrow transplantation that was refractory to rituximab treatment. Similar to other types of lymphoma, the absence of CD20 antigen is likely to be characteristic of rituximab-refractory EBV-PTLD.

Original language	English
Pages (from-to)	779-781
Number of pages	3
Journal	International journal of hematology
Volume	93
Issue number	6
DOIs	https://doi.org/10.1007/s12185-011-0870-3
Publication status	Published - Jun 2011

Keywords

Aplastic anemia
CD20
Epstein-Barr virus
Post-transplant lymphoproliferative disease
Rituximab
Unrelated bone marrow transplantation

ASJC Scopus subject areas

Hematology

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Muramatsu, H., Takahashi, Y., Shimoyama, Y., Doisaki, S., Nishio, N., Ito, Y., Hama, A., Shimada, A., Yagasaki, H., Ito, M., & Kojima, S. (2011). CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia. International journal of hematology, 93(6), 779-781. https://doi.org/10.1007/s12185-011-0870-3

CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia. / Muramatsu, Hideki; Takahashi, Yoshiyuki; Shimoyama, Yoshie; Doisaki, Sayoko; Nishio, Nobuhiro; Ito, Yoshinori; Hama, Asahito; Shimada, Akira; Yagasaki, Hiroshi; Ito, Masafumi; Kojima, Seiji.

In: International journal of hematology, Vol. 93, No. 6, 06.2011, p. 779-781.

Research output: Contribution to journal › Article › peer-review

Muramatsu, H, Takahashi, Y, Shimoyama, Y, Doisaki, S, Nishio, N, Ito, Y, Hama, A, Shimada, A, Yagasaki, H, Ito, M & Kojima, S 2011, 'CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia', International journal of hematology, vol. 93, no. 6, pp. 779-781. https://doi.org/10.1007/s12185-011-0870-3

Muramatsu, Hideki ; Takahashi, Yoshiyuki ; Shimoyama, Yoshie ; Doisaki, Sayoko ; Nishio, Nobuhiro ; Ito, Yoshinori ; Hama, Asahito ; Shimada, Akira ; Yagasaki, Hiroshi ; Ito, Masafumi ; Kojima, Seiji. / CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia. In: International journal of hematology. 2011 ; Vol. 93, No. 6. pp. 779-781.

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abstract = "Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV-PTLD) is a life-threatening complication following allogeneic hematopoietic stem cell transplantation (HSCT). Monitoring of EBV DNA in high-risk patients with subsequent pre-emptive rituximab treatment is highly effective, and can prevent EBV-associated disease following HSCT. Here, we report a 10-year-old girl with aplastic anemia who developed CD20 negative EBV-PTLD after unrelated bone marrow transplantation that was refractory to rituximab treatment. Similar to other types of lymphoma, the absence of CD20 antigen is likely to be characteristic of rituximab-refractory EBV-PTLD.",

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