CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia

Hideki Muramatsu; Yoshiyuki Takahashi; Yoshie Shimoyama; Sayoko Doisaki; Nobuhiro Nishio; Yoshinori Ito; Asahito Hama; Akira Shimada; Hiroshi Yagasaki; Masafumi Ito; Seiji Kojima

doi:10.1007/s12185-011-0870-3

CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia

Hideki Muramatsu, Yoshiyuki Takahashi, Yoshie Shimoyama, Sayoko Doisaki, Nobuhiro Nishio, Yoshinori Ito, Asahito Hama, Akira Shimada, Hiroshi Yagasaki, Masafumi Ito, Seiji Kojima

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV-PTLD) is a life-threatening complication following allogeneic hematopoietic stem cell transplantation (HSCT). Monitoring of EBV DNA in high-risk patients with subsequent pre-emptive rituximab treatment is highly effective, and can prevent EBV-associated disease following HSCT. Here, we report a 10-year-old girl with aplastic anemia who developed CD20 negative EBV-PTLD after unrelated bone marrow transplantation that was refractory to rituximab treatment. Similar to other types of lymphoma, the absence of CD20 antigen is likely to be characteristic of rituximab-refractory EBV-PTLD.

Original language	English
Pages (from-to)	779-781
Number of pages	3
Journal	International journal of hematology
Volume	93
Issue number	6
DOIs	https://doi.org/10.1007/s12185-011-0870-3
Publication status	Published - Jun 2011
Externally published	Yes

Keywords

Aplastic anemia
CD20
Epstein-Barr virus
Post-transplant lymphoproliferative disease
Rituximab
Unrelated bone marrow transplantation

ASJC Scopus subject areas

Hematology

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Muramatsu, H., Takahashi, Y., Shimoyama, Y., Doisaki, S., Nishio, N., Ito, Y., Hama, A., Shimada, A., Yagasaki, H., Ito, M., & Kojima, S. (2011). CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia. International journal of hematology, 93(6), 779-781. https://doi.org/10.1007/s12185-011-0870-3

CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia. / Muramatsu, Hideki; Takahashi, Yoshiyuki; Shimoyama, Yoshie; Doisaki, Sayoko; Nishio, Nobuhiro; Ito, Yoshinori; Hama, Asahito; Shimada, Akira; Yagasaki, Hiroshi; Ito, Masafumi; Kojima, Seiji.

In: International journal of hematology, Vol. 93, No. 6, 06.2011, p. 779-781.

Research output: Contribution to journal › Article › peer-review

Muramatsu, H, Takahashi, Y, Shimoyama, Y, Doisaki, S, Nishio, N, Ito, Y, Hama, A, Shimada, A, Yagasaki, H, Ito, M & Kojima, S 2011, 'CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia', International journal of hematology, vol. 93, no. 6, pp. 779-781. https://doi.org/10.1007/s12185-011-0870-3

Muramatsu, Hideki ; Takahashi, Yoshiyuki ; Shimoyama, Yoshie ; Doisaki, Sayoko ; Nishio, Nobuhiro ; Ito, Yoshinori ; Hama, Asahito ; Shimada, Akira ; Yagasaki, Hiroshi ; Ito, Masafumi ; Kojima, Seiji. / CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia. In: International journal of hematology. 2011 ; Vol. 93, No. 6. pp. 779-781.

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abstract = "Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV-PTLD) is a life-threatening complication following allogeneic hematopoietic stem cell transplantation (HSCT). Monitoring of EBV DNA in high-risk patients with subsequent pre-emptive rituximab treatment is highly effective, and can prevent EBV-associated disease following HSCT. Here, we report a 10-year-old girl with aplastic anemia who developed CD20 negative EBV-PTLD after unrelated bone marrow transplantation that was refractory to rituximab treatment. Similar to other types of lymphoma, the absence of CD20 antigen is likely to be characteristic of rituximab-refractory EBV-PTLD.",

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AU - Doisaki, Sayoko

AU - Nishio, Nobuhiro

AU - Ito, Yoshinori

AU - Hama, Asahito

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AU - Yagasaki, Hiroshi

AU - Ito, Masafumi

AU - Kojima, Seiji

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AB - Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV-PTLD) is a life-threatening complication following allogeneic hematopoietic stem cell transplantation (HSCT). Monitoring of EBV DNA in high-risk patients with subsequent pre-emptive rituximab treatment is highly effective, and can prevent EBV-associated disease following HSCT. Here, we report a 10-year-old girl with aplastic anemia who developed CD20 negative EBV-PTLD after unrelated bone marrow transplantation that was refractory to rituximab treatment. Similar to other types of lymphoma, the absence of CD20 antigen is likely to be characteristic of rituximab-refractory EBV-PTLD.

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CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia

Abstract

Keywords

ASJC Scopus subject areas

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