CD10 down expression in follicular lymphoma correlates with gastrointestinal lesion involving the stomach and large intestine

Nobuhiko Ohnishi, Katsuyoshi Takata, Tomoko Miyata-Takata, Yasuharu Sato, Akira Tari, Yuka Gion, Mai Noujima-Harada, Kouhei Taniguchi, Tetsuya Tabata, Keina Nagakita, Shizuma Omote, Hiroyuki Takahata, Masaya Iwamuro, Hiroyuki Okada, Yoshinobu Maeda, Hiroyuki Yanai, Tadashi Yoshino

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Follicular lymphoma (FL) shows co-expression of B-cell lymphoma 2 (BCL2) and CD10, whereas downexpression of CD10 is occasionally experienced in gastrointestinal (GI) FL with unknown significance. Gastrointestinal FL is a rare variant of FL, and its similarity with mucosa-associated lymphoid tissue lymphoma was reported. We investigated the clinicopathological and genetic features of CD10 downexpressed (CD10down) GI-FL. The diagnosis of CD10down FL was carried out with a combination of pathological and molecular analyses. The incidence of CD10down GI-FL was shown in 35/172 (20.3%) cases, which was more frequent than nodal FL (3.5%, P < 0.001). The difference was additionally significant between GI-FL and nodal FL when the analysis was confined to primary GI-FL (55.2% vs 3.5%, P < 0.001). Compared to CD10+ GI-FL, CD10down GI-FL significantly involved the stomach or large intestine (P = 0.015), and additionally showed the downexpression of BCL6 (P < 0.001). The follicular dendritic cell meshwork often showed a duodenal pattern in the CD10down group (P = 0.12). Furthermore, a lymphoepithelial lesion was observed in 5/12 (40%) gastric FL cases, which indicated caution in the differentiation of mucosa-associated lymphoid tissue lymphoma. Molecular analyses were undertaken in seven cases of CD10down GI-FL, and an identical clone was found between CD10down follicles and CD10+BCL2+ neoplastic follicles. In the diagnosis of cases with CD10down BCL2+ follicles, careful examination with molecular studies should be carried out.

Original languageEnglish
Pages (from-to)1687-1695
Number of pages9
JournalCancer Science
Volume107
Issue number11
DOIs
Publication statusPublished - Nov 1 2016

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Follicular Lymphoma
Large Intestine
Stomach
B-Cell Lymphoma
Marginal Zone B-Cell Lymphoma
Follicular Dendritic Cells

Keywords

  • CD10
  • downexpression
  • follicular lymphoma
  • gastrointestinal tract
  • involvement of stomach and large intestine

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

CD10 down expression in follicular lymphoma correlates with gastrointestinal lesion involving the stomach and large intestine. / Ohnishi, Nobuhiko; Takata, Katsuyoshi; Miyata-Takata, Tomoko; Sato, Yasuharu; Tari, Akira; Gion, Yuka; Noujima-Harada, Mai; Taniguchi, Kouhei; Tabata, Tetsuya; Nagakita, Keina; Omote, Shizuma; Takahata, Hiroyuki; Iwamuro, Masaya; Okada, Hiroyuki; Maeda, Yoshinobu; Yanai, Hiroyuki; Yoshino, Tadashi.

In: Cancer Science, Vol. 107, No. 11, 01.11.2016, p. 1687-1695.

Research output: Contribution to journalArticle

Ohnishi, Nobuhiko ; Takata, Katsuyoshi ; Miyata-Takata, Tomoko ; Sato, Yasuharu ; Tari, Akira ; Gion, Yuka ; Noujima-Harada, Mai ; Taniguchi, Kouhei ; Tabata, Tetsuya ; Nagakita, Keina ; Omote, Shizuma ; Takahata, Hiroyuki ; Iwamuro, Masaya ; Okada, Hiroyuki ; Maeda, Yoshinobu ; Yanai, Hiroyuki ; Yoshino, Tadashi. / CD10 down expression in follicular lymphoma correlates with gastrointestinal lesion involving the stomach and large intestine. In: Cancer Science. 2016 ; Vol. 107, No. 11. pp. 1687-1695.
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abstract = "Follicular lymphoma (FL) shows co-expression of B-cell lymphoma 2 (BCL2) and CD10, whereas downexpression of CD10 is occasionally experienced in gastrointestinal (GI) FL with unknown significance. Gastrointestinal FL is a rare variant of FL, and its similarity with mucosa-associated lymphoid tissue lymphoma was reported. We investigated the clinicopathological and genetic features of CD10 downexpressed (CD10down) GI-FL. The diagnosis of CD10down FL was carried out with a combination of pathological and molecular analyses. The incidence of CD10down GI-FL was shown in 35/172 (20.3{\%}) cases, which was more frequent than nodal FL (3.5{\%}, P < 0.001). The difference was additionally significant between GI-FL and nodal FL when the analysis was confined to primary GI-FL (55.2{\%} vs 3.5{\%}, P < 0.001). Compared to CD10+ GI-FL, CD10down GI-FL significantly involved the stomach or large intestine (P = 0.015), and additionally showed the downexpression of BCL6 (P < 0.001). The follicular dendritic cell meshwork often showed a duodenal pattern in the CD10down group (P = 0.12). Furthermore, a lymphoepithelial lesion was observed in 5/12 (40{\%}) gastric FL cases, which indicated caution in the differentiation of mucosa-associated lymphoid tissue lymphoma. Molecular analyses were undertaken in seven cases of CD10down GI-FL, and an identical clone was found between CD10down follicles and CD10+BCL2+ neoplastic follicles. In the diagnosis of cases with CD10down BCL2+ follicles, careful examination with molecular studies should be carried out.",
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AU - Ohnishi, Nobuhiko

AU - Takata, Katsuyoshi

AU - Miyata-Takata, Tomoko

AU - Sato, Yasuharu

AU - Tari, Akira

AU - Gion, Yuka

AU - Noujima-Harada, Mai

AU - Taniguchi, Kouhei

AU - Tabata, Tetsuya

AU - Nagakita, Keina

AU - Omote, Shizuma

AU - Takahata, Hiroyuki

AU - Iwamuro, Masaya

AU - Okada, Hiroyuki

AU - Maeda, Yoshinobu

AU - Yanai, Hiroyuki

AU - Yoshino, Tadashi

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N2 - Follicular lymphoma (FL) shows co-expression of B-cell lymphoma 2 (BCL2) and CD10, whereas downexpression of CD10 is occasionally experienced in gastrointestinal (GI) FL with unknown significance. Gastrointestinal FL is a rare variant of FL, and its similarity with mucosa-associated lymphoid tissue lymphoma was reported. We investigated the clinicopathological and genetic features of CD10 downexpressed (CD10down) GI-FL. The diagnosis of CD10down FL was carried out with a combination of pathological and molecular analyses. The incidence of CD10down GI-FL was shown in 35/172 (20.3%) cases, which was more frequent than nodal FL (3.5%, P < 0.001). The difference was additionally significant between GI-FL and nodal FL when the analysis was confined to primary GI-FL (55.2% vs 3.5%, P < 0.001). Compared to CD10+ GI-FL, CD10down GI-FL significantly involved the stomach or large intestine (P = 0.015), and additionally showed the downexpression of BCL6 (P < 0.001). The follicular dendritic cell meshwork often showed a duodenal pattern in the CD10down group (P = 0.12). Furthermore, a lymphoepithelial lesion was observed in 5/12 (40%) gastric FL cases, which indicated caution in the differentiation of mucosa-associated lymphoid tissue lymphoma. Molecular analyses were undertaken in seven cases of CD10down GI-FL, and an identical clone was found between CD10down follicles and CD10+BCL2+ neoplastic follicles. In the diagnosis of cases with CD10down BCL2+ follicles, careful examination with molecular studies should be carried out.

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