CCN proteins: A new family of cell growth and differentiation regulators

Bernard Perbal, Masaharu Takigawa

Research output: Book/ReportBook

126 Citations (Scopus)


The CCN Proteins are thought to play key roles in the biology of normal cell, tissue, organ, and body, and altered expression of CCN proteins is associated with several pathologies, including fibrosis and cancer. Because of its importance, the CCN field is expanding at a fast pace. Research articles in this field have recently increased logarithmically, and a book that is up-to-date, comprehensive, authoritative and affords insights into the biological roles of CCN proteins, is timely. CCN Protein: A New Family of Cell Growth and Differentiation Regulators presents the most recent progress in the field of CCN proteins, a new family of secretory signaling molecules that are involved in several fundamental biological progress. These proteins share a unique multimodular organization and present a partial identity with four families of regulatory proteins controling growth and development. The book covers the roles of CCN proteins in the control of cell proliferation and differentiation during normal development, wound repair, chondrogenesis and bone development, angiogenesis, tissue regeneration, fibrosis, renal diseases and cancer development.

Original languageEnglish
PublisherImperial College Press
Number of pages311
ISBN (Electronic)9781860946899
ISBN (Print)9781860945526
Publication statusPublished - Jan 1 2005

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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