Cavitary pulmonary involvement of diffuse large B-cell lymphoma transformed from extra nodal marginal zone B-cell lymphoma MALT type

Hiromichi Yamane, Masahiro Ohsawa, Yasuhiro Shiote, Shigeki Umemura, Toshimitsu Suwaki, Atsuko Shirakawa, Haruhito Kamei, Nagio Takigawa, Katsuyuki Kiura

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We describe a case of pulmonary diffuse large B-cell lymphoma (DLBCL), which was thought to arise from extranodal marginal zone lymphoma of mucosaassociated lymphoid tissue (MALT lymphoma). A 68- year-old woman presented with a 2-month history of cough and bloody sputum. The chest X-ray and computed tomography revealed a mass with cavitation in the right lower lobe. Transbronchial biopsy specimens revealed a granulomatous infiltration without malignant cells. However, diagnosis of MALT lymphoma was established from gastric biopsy specimen. Subsequently, a right lower lobectomy was performed because of hemoptysis. Examination of the resected specimen revealed a diffuse large B-cell lymphoma, which was considered to have transformed from MALT lymphoma, because both lung and stomach lesions had the chromosomal translocation t(11;18)(q21;q21) in common. In addition, there were no nodules, masses, alveolar or interstitial infiltrates in the lung fields, which are usually observed in the case of marginal zone B-cell lymphoma of bronchial mucosaassociated lymphoid tissue. These findings indicate that involvement of DLBCL have to be considered in patients with MALT lymphoma and cavitary lesion of the lung.

Original languageEnglish
Pages (from-to)401-406
Number of pages6
JournalClinical Journal of Gastroenterology
Issue number6
Publication statusPublished - Dec 2011



  • Cavitation
  • Diffuse large B-cell lymphoma
  • MALT lymphoma
  • Primary lung cancer

ASJC Scopus subject areas

  • Gastroenterology

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