Caveolin-1 as tumor suppressor gene in breast cancer

Masato Hino, Hiroyoshi Doihara, Kazuyasu Kobayashi, Motoi Aoe, Nobuyoshi Shimizu

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Purpose. Many articles have reported the caveolin-1 gene to be downregulated thus suggesting that it might be a candidate tumor suppressor gene in many tumors, but in bladder tumors the caveolin-1 gene was expressed and related to the pathological grade. We investigated the function of caveolin-1 protein in breast tumors. Methods. We introduced the caveolin-1 gene into a MCF-7 human breast cancer cell line, and examined its cell growth, cell viability, and anchorage-independent growth. Results. The caveolin-1 transfectants showed less proliferation than the vector control transfectants on the fourth day regarding the cell growth rate. In addition, the cell viability of the caveolin-1 transfectants was about 55 % of the vector control. A soft agar assay of the caveolin-1 transfectants showed less growth with a lower number of colonies. Conclusion. In MCF-7 cells, the caveolin-1 gene may influence the tumor suppressor efficacy.

Original languageEnglish
Pages (from-to)486-490
Number of pages5
JournalSurgery Today
Volume33
Issue number7
Publication statusPublished - 2003

Fingerprint

Caveolin 1
Tumor Suppressor Genes
Breast Neoplasms
Growth
Genes
Cell Survival
Caveolins
MCF-7 Cells
Urinary Bladder Neoplasms
Agar
Neoplasms
Down-Regulation
Cell Line

Keywords

  • Caveolin-1
  • Cell growth
  • MCF-7

ASJC Scopus subject areas

  • Surgery

Cite this

Hino, M., Doihara, H., Kobayashi, K., Aoe, M., & Shimizu, N. (2003). Caveolin-1 as tumor suppressor gene in breast cancer. Surgery Today, 33(7), 486-490.

Caveolin-1 as tumor suppressor gene in breast cancer. / Hino, Masato; Doihara, Hiroyoshi; Kobayashi, Kazuyasu; Aoe, Motoi; Shimizu, Nobuyoshi.

In: Surgery Today, Vol. 33, No. 7, 2003, p. 486-490.

Research output: Contribution to journalArticle

Hino, M, Doihara, H, Kobayashi, K, Aoe, M & Shimizu, N 2003, 'Caveolin-1 as tumor suppressor gene in breast cancer', Surgery Today, vol. 33, no. 7, pp. 486-490.
Hino M, Doihara H, Kobayashi K, Aoe M, Shimizu N. Caveolin-1 as tumor suppressor gene in breast cancer. Surgery Today. 2003;33(7):486-490.
Hino, Masato ; Doihara, Hiroyoshi ; Kobayashi, Kazuyasu ; Aoe, Motoi ; Shimizu, Nobuyoshi. / Caveolin-1 as tumor suppressor gene in breast cancer. In: Surgery Today. 2003 ; Vol. 33, No. 7. pp. 486-490.
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