CAV-PVP chemotherapy and sequential thoracic irradiation (TI) for patients with limited (LD) small cell lung cancer (SCLC)

H. Ueoka, T. Ohnoshi, S. Hiraki, H. Kamei, Masahiro Tabata, T. Shibayama, K. Miyatake, K. Gemba, J. Hiyama, J. Kimura

Research output: Contribution to journalArticle

Abstract

In order to assess the effectiveness of sequential TI for the treatment of LD SCLC, we analyzed 69 patients who had received CAV-PVP chemotherapy consisting of cyclophosphamide, adriamycin, vincristine, cisplatin and etoposide, plus sequential TI between 1986 and 1992. TI was delivered at a total dose of 50 Gy, 5 fractions/week for 5 weeks, once patients achieved a maximal response to chemotherapy. Responding patients also received PCI at a total dose of 30 Gy, 5 fractions/week for 3 weeks. Thirty patients achieved CR by chemotherapy and an additional 10 achieved CR after TI, resulting in a CR rate of 58.0%. Of 40 patients achieving CR, 24 have relapsed so far; the primary (in 15) and the brain (in 4) were the major sites of relapse despite TI and PCI. The median survival time was 18.4 months, with a 2-year survival rate of 39% and 3-year survival rate of 20%. Almost all the patients encountered grade 3 or grade 4 leukopenia while receiving chemotherapy, but the toxicity of TI was generaly mild. This treatment is useful for patients with LD SCLC.

Original languageEnglish
Pages (from-to)218-224
Number of pages7
JournalJapanese Journal of Thoracic Diseases
Volume31
Issue numberSUPPL.
Publication statusPublished - 1993

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Small Cell Lung Carcinoma
Thorax
Drug Therapy
Survival Rate
Leukopenia
Vincristine
Etoposide
Doxorubicin
Cyclophosphamide
Cisplatin
Recurrence
Survival
Brain
Therapeutics

Keywords

  • chemo-radiotherapy
  • sequential therapy
  • small cell lung cancer

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

CAV-PVP chemotherapy and sequential thoracic irradiation (TI) for patients with limited (LD) small cell lung cancer (SCLC). / Ueoka, H.; Ohnoshi, T.; Hiraki, S.; Kamei, H.; Tabata, Masahiro; Shibayama, T.; Miyatake, K.; Gemba, K.; Hiyama, J.; Kimura, J.

In: Japanese Journal of Thoracic Diseases, Vol. 31, No. SUPPL., 1993, p. 218-224.

Research output: Contribution to journalArticle

Ueoka, H, Ohnoshi, T, Hiraki, S, Kamei, H, Tabata, M, Shibayama, T, Miyatake, K, Gemba, K, Hiyama, J & Kimura, J 1993, 'CAV-PVP chemotherapy and sequential thoracic irradiation (TI) for patients with limited (LD) small cell lung cancer (SCLC)', Japanese Journal of Thoracic Diseases, vol. 31, no. SUPPL., pp. 218-224.
Ueoka, H. ; Ohnoshi, T. ; Hiraki, S. ; Kamei, H. ; Tabata, Masahiro ; Shibayama, T. ; Miyatake, K. ; Gemba, K. ; Hiyama, J. ; Kimura, J. / CAV-PVP chemotherapy and sequential thoracic irradiation (TI) for patients with limited (LD) small cell lung cancer (SCLC). In: Japanese Journal of Thoracic Diseases. 1993 ; Vol. 31, No. SUPPL. pp. 218-224.
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AU - Ohnoshi, T.

AU - Hiraki, S.

AU - Kamei, H.

AU - Tabata, Masahiro

AU - Shibayama, T.

AU - Miyatake, K.

AU - Gemba, K.

AU - Hiyama, J.

AU - Kimura, J.

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N2 - In order to assess the effectiveness of sequential TI for the treatment of LD SCLC, we analyzed 69 patients who had received CAV-PVP chemotherapy consisting of cyclophosphamide, adriamycin, vincristine, cisplatin and etoposide, plus sequential TI between 1986 and 1992. TI was delivered at a total dose of 50 Gy, 5 fractions/week for 5 weeks, once patients achieved a maximal response to chemotherapy. Responding patients also received PCI at a total dose of 30 Gy, 5 fractions/week for 3 weeks. Thirty patients achieved CR by chemotherapy and an additional 10 achieved CR after TI, resulting in a CR rate of 58.0%. Of 40 patients achieving CR, 24 have relapsed so far; the primary (in 15) and the brain (in 4) were the major sites of relapse despite TI and PCI. The median survival time was 18.4 months, with a 2-year survival rate of 39% and 3-year survival rate of 20%. Almost all the patients encountered grade 3 or grade 4 leukopenia while receiving chemotherapy, but the toxicity of TI was generaly mild. This treatment is useful for patients with LD SCLC.

AB - In order to assess the effectiveness of sequential TI for the treatment of LD SCLC, we analyzed 69 patients who had received CAV-PVP chemotherapy consisting of cyclophosphamide, adriamycin, vincristine, cisplatin and etoposide, plus sequential TI between 1986 and 1992. TI was delivered at a total dose of 50 Gy, 5 fractions/week for 5 weeks, once patients achieved a maximal response to chemotherapy. Responding patients also received PCI at a total dose of 30 Gy, 5 fractions/week for 3 weeks. Thirty patients achieved CR by chemotherapy and an additional 10 achieved CR after TI, resulting in a CR rate of 58.0%. Of 40 patients achieving CR, 24 have relapsed so far; the primary (in 15) and the brain (in 4) were the major sites of relapse despite TI and PCI. The median survival time was 18.4 months, with a 2-year survival rate of 39% and 3-year survival rate of 20%. Almost all the patients encountered grade 3 or grade 4 leukopenia while receiving chemotherapy, but the toxicity of TI was generaly mild. This treatment is useful for patients with LD SCLC.

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