Cathepsin E

An Aspartic Protease with Diverse Functions and Biomedical Implications

K. Yamamoto, Kuniaki Okamoto, T. Tsukuba

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Aspartic peptidases are widely distributed among vertebrates, yeast, plants, fungi, bacteria, and viruses. Of these, the A1 family members, including cathepsin E and ß-secretase, are involved in specific and/or nonspecific degradation of proteins and peptides in intra- and/or extracellular spaces. In the last decade, cathepsin E and ß-secretase have received enormous interest because of their involvement in important biological processes and the close association of their abnormal expression and uncontrolled activity with human diseases. This review summarizes the current knowledge on biochemical properties and functions of cathepsin E and highlights the pathophysiological conditions caused by its deficiency.

Original languageEnglish
Title of host publicationMolecular Cell Biology
PublisherElsevier Inc.
Pages681-690
Number of pages10
Volume1
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
DOIs
Publication statusPublished - Jan 1 2015
Externally publishedYes

Fingerprint

Cathepsin E
Amyloid Precursor Protein Secretases
Peptide Hydrolases
Biological Phenomena
Extracellular Space
Human Activities
Proteolysis
Vertebrates
Fungi
Yeasts
Viruses
Bacteria
Peptides

Keywords

  • Activation
  • Angiogenesis
  • Apoptosis
  • Aspartic peptidases
  • Cancer
  • Cathepsin E
  • Drugs
  • Endosomal/lysosomal system
  • Inhibitors
  • Neurodegeneration
  • Pathogenesis
  • Pepsin subfamily
  • Processing and trafficking
  • Proliferation
  • Signaling

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Yamamoto, K., Okamoto, K., & Tsukuba, T. (2015). Cathepsin E: An Aspartic Protease with Diverse Functions and Biomedical Implications. In Molecular Cell Biology (Vol. 1, pp. 681-690). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-394447-4.10078-1

Cathepsin E : An Aspartic Protease with Diverse Functions and Biomedical Implications. / Yamamoto, K.; Okamoto, Kuniaki; Tsukuba, T.

Molecular Cell Biology. Vol. 1 Elsevier Inc., 2015. p. 681-690.

Research output: Chapter in Book/Report/Conference proceedingChapter

Yamamoto, K. ; Okamoto, Kuniaki ; Tsukuba, T. / Cathepsin E : An Aspartic Protease with Diverse Functions and Biomedical Implications. Molecular Cell Biology. Vol. 1 Elsevier Inc., 2015. pp. 681-690
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