Catechol derivatives inhibit the fibril formation of amyloid-β peptides

Vu Thi Huong, Toshinori Shimanouchi, Naoya Shimauchi, Hisashi Yagi, Hiroshi Umakoshi, Yuji Goto, Ryoichi Kuboi

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The inhibition of fibril formation of amyloid β proteins (Aβ) would be attractive therapeutic targets for the treatment of Alzheimer's disease (AD). Dopamine (DA) and other catechol derivatives were used as inhibitory factors for Aβ fibril formation. The fibril formation of Aβ was monitored by Thioflavin T fluorescence, a transmission electron microscopy (TEM) and a total internal reflection fluorescence microscopy (TIRFM). Catechol and its derivatives showed the dose-dependent inhibitory effects on the spontaneous Aβ fibril formation. The inhibitory activity depended on the chemical structure of catechol derivatives both in the presence and absence of the liposome a model of biomembrane. Formation of catechol quinone-conjugated-Aβ adduct by a Schiff-base is a key step for the inhibition effect of Aβ fibril formation.

Original languageEnglish
Pages (from-to)629-634
Number of pages6
JournalJournal of Bioscience and Bioengineering
Volume109
Issue number6
DOIs
Publication statusPublished - Jun 1 2010
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amyloid beta
  • Catechol derivatives
  • Fibril formation
  • Inhibitor
  • Liposome

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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