Catalytic synthesis of peptide-derived thiazolines and oxazolines using bis(quinolinolato)dioxomolybdenum(VI) complexes

Akira Sakakura, Rei Kondo, Shuhei Umemura, Kazuaki Ishihara

Research output: Contribution to journalArticle

21 Citations (Scopus)


Bis(2-ethyl-8-quinolinolato)dioxomolybdenum(VI) (9) (1 mol %) shows remarkable catalytic activity for the dehydrative cyclization of cysteine-containing dipeptides 1 to give the corresponding thiazolines 2 with less than 6 % epimerization at the C2-exomethine position. For the dehydrative cyclization of threonine-containing dipeptides 4, 1 mol % of bis(2-phenyl-8-quinolinolato)dioxomolybdenum(VI) (10) gives the corresponding oxazolines 5 with retention of configuration at the 5-position.

Original languageEnglish
Pages (from-to)1641-1646
Number of pages6
JournalAdvanced Synthesis and Catalysis
Issue number10
Publication statusPublished - Jul 2007
Externally publishedYes



  • Catalysis
  • Dehydrative cyclization
  • Molybdenum
  • Oxazolines
  • Quinolinolato species
  • Thiazolines

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Organic Chemistry
  • Catalysis

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