Catalytic guanylation of aliphatic, aromatic, heterocyclic primary and secondary amines using nanocrystalline zinc(II) oxide

M. Lakshmi Kantam, S. Priyadarshini, P. J. Amal Joseph, P. Srinivas, A. Vinu, K. J. Klabunde, Yuta Nishina

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Nanocrystalline ZnO was found to be a highly efficient heterogeneous catalyst for the guanylation of amines with various carbodiimides to afford N,N′,N″-trisubstituted guanidines in excellent yields. Structurally divergent aliphatic, aromatic, heterocyclic primary and secondary amines were converted to the corresponding N,N′,N″-trisubstituted guanidines using optimal conditions. The catalyst was easy to handle even under atmospheric conditions and can be easily recovered by centrifugation and reused for five cycles with consistent activity.

Original languageEnglish
Pages (from-to)5730-5737
Number of pages8
JournalTetrahedron
Volume68
Issue number29
DOIs
Publication statusPublished - Jul 22 2012

Keywords

  • Amines
  • Carbodiimides
  • Guanylation
  • Heterogeneous catalysis
  • Nanocrystalline zinc oxide

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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