Catalytic enantioselective inverse electron demand hetero-diels-alder reaction with allylsilanes

Yuki Matsumura, Takahiro Suzuki, Akira Sakakura, Kazuaki Ishihara

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The first diastereo- and enantioselective inverse electron demand hetero-Diels-Alder reaction of β,γ-unsaturated α-ketoesters with allylsilanes is described. Chiral copper(II) catalysts successfully activate the β,γ-unsaturated α-ketoesters and promote the reaction with allylsilanes with excellent enantioselectivities. This process represents a new entry to chiral oxanes.

Original languageEnglish
Pages (from-to)6131-6134
Number of pages4
JournalAngewandte Chemie - International Edition
Volume53
Issue number24
DOIs
Publication statusPublished - Jun 10 2014

Keywords

  • Lewis acid
  • asymmetric catalysis
  • copper
  • cycloaddition
  • heterocycles

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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