Cartilaginous differentiation in the joint capsule

Yasutaka Yutani, Yoshihisa Yano, Hirotsugu Ohashi, Masaharu Takigawa, Yoshiki Yamano

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The proliferation and differentiation of cells are greatly influenced by their environment. Many growth factors and cytokines are reported to be environmental factors that affect the proliferation and differentiation of cells. Mechanical stress is also considered to influence these physiological reactions. The joint capsule, which is a part of the joint tissue, plays a very important role in the stability of the joint and in maintaining the intracapsular phenomenon. In patients with dislocated hip arthropathy, this capsule is involved in the weightbearing function by forming a sliding surface between the capsule and the femoral head articular cartilage. The surface of the tissue macroscopically shows cartilaginous change, which indicates cartilaginous differentiation caused by mechanical stress. We examined the cartilage-specific proteoglycan component, which is composed of cartilaginou matrix at the differentiation site. We investigated proteoglycan production, molecular size, and the gene expression of cartilaginous substrate. At the inner layer of the weightbearing area of the joint capsule, proteoglycan production was significantly higher than that of other noncartilaginous tissue. We also identified the gene expression of cartilaginous proteoglycan using the reverse transcription polymerase chain reaction (RT-PCR) method.

Original languageEnglish
Pages (from-to)7-10
Number of pages4
JournalJournal of Bone and Mineral Metabolism
Volume17
Issue number1
DOIs
Publication statusPublished - 1999

Fingerprint

Joint Capsule
Proteoglycans
Mechanical Stress
Weight-Bearing
Capsules
Cell Differentiation
Joints
Cell Proliferation
Gene Expression
Joint Diseases
Articular Cartilage
Thigh
Reverse Transcription
Cartilage
Hip
Intercellular Signaling Peptides and Proteins
Cytokines
Polymerase Chain Reaction

Keywords

  • Differentiation
  • Joint capsule
  • Proteoglycan

ASJC Scopus subject areas

  • Endocrinology

Cite this

Cartilaginous differentiation in the joint capsule. / Yutani, Yasutaka; Yano, Yoshihisa; Ohashi, Hirotsugu; Takigawa, Masaharu; Yamano, Yoshiki.

In: Journal of Bone and Mineral Metabolism, Vol. 17, No. 1, 1999, p. 7-10.

Research output: Contribution to journalArticle

Yutani, Yasutaka ; Yano, Yoshihisa ; Ohashi, Hirotsugu ; Takigawa, Masaharu ; Yamano, Yoshiki. / Cartilaginous differentiation in the joint capsule. In: Journal of Bone and Mineral Metabolism. 1999 ; Vol. 17, No. 1. pp. 7-10.
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