Cartilage-derived anti-tumor factor (CATF) inhibits the proliferation of endothelial cells in culture

Masaharu Takigawa, Eiji Shirai, Motomi Enomoto, Yuji Hiraki, Michiko Fukuya, Fujio Suzuki, Tsuyoshi Shiio, Yasumi Yugari

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20 Citations (Scopus)

Abstract

Previous studies showed that a cartilage-derived anti-tumor factor (CATF), which was extracted from bovine cartilage with l M guanidine hydrochloride, inhibited the growth of solid sarcoma 180, but not the growth of ascites tumors of sarcoma 180 [Suzuki, F. et al. Jpn. J. Bone Metab., 2, 231-235 (1984)]. This study showed that CATF inhibited the proliferation and DNA synthesis of endothelial cells isolated from bovine pulmonary artery, but not the proliferations of sarcoma 180, L1210 and L cells. These results suggest that CATF has anti-angiogenic properties, thereby inhibiting the growth of solid tumors.

Original languageEnglish
Pages (from-to)619-625
Number of pages7
JournalCell Biology International Reports
Volume9
Issue number7
DOIs
Publication statusPublished - Jul 1985

ASJC Scopus subject areas

  • Cell Biology

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