Carrier rate of Factor XI deficiency in stunted Japanese black cattle

Daisaku Watanabe, Takashi Hirano, Yoshikazu Sugimoto, Yoshimi Ogata, Shogo Abe, Takaaki Ando, Hiromichi Ohtsuka, Tetsuo Kunieda, Seiichi Kawamura

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Blood examinations and genotyping of Factor XI (F11) were performed in growth retardation Japanese Black cattle and their dams. Genotyping of F11 revealed that the recessive homozygous and heterozygous genotype frequencies were 5.2% and 50.0% in the Claudin-16 (CL-16) deficiency group (n=58), 0% and 14.2% in the renal dysplasia group (n=7), 0% and 26.1% in the non-CL-16 deficiency nephritis group (n=23), 8.9% and 46.7% in the hypogenesis syndrome group (n=45), 6.2% and 25.0% in the neonatal weak calf syndrome group (n=32), 9.1% and 38.6% in the respective dams group (n=44), 0% and 23.1% in the normal cattle group (n=13), and 5.9% and 38.2% in total (n=222), respectively. These results showed that the carrier rate of F11 deficiency was high in Japanese Black cattle, and that the CL-16 deficiency, hypogenesis syndrome, neonatal weak calf syndrome, and dams groups had a large amount of recessive homozygous genotype than the other groups. No abnormal bleeding was observed clinically in the present study, and 4 of the recessive homozygous dams showed normal growth and parturition.

Original languageEnglish
Pages (from-to)1251-1255
Number of pages5
JournalJournal of Veterinary Medical Science
Volume68
Issue number12
DOIs
Publication statusPublished - Dec 2006

Fingerprint

Factor XI Deficiency
Wagyu
homozygosity
genotyping
cattle
calves
nephritis
Genotype
Factor XI
growth retardation
hemorrhage
Nephritis
heterozygosity
Growth
kidneys
parturition
blood
Parturition
Hemorrhage
Kidney

Keywords

  • Claudin-16 deficiency
  • Factor XI deficiency
  • Growth retardation
  • Hypogenesis
  • Japanese Black cattle

ASJC Scopus subject areas

  • veterinary(all)
  • Marketing

Cite this

Watanabe, D., Hirano, T., Sugimoto, Y., Ogata, Y., Abe, S., Ando, T., ... Kawamura, S. (2006). Carrier rate of Factor XI deficiency in stunted Japanese black cattle. Journal of Veterinary Medical Science, 68(12), 1251-1255. https://doi.org/10.1292/jvms.68.1251

Carrier rate of Factor XI deficiency in stunted Japanese black cattle. / Watanabe, Daisaku; Hirano, Takashi; Sugimoto, Yoshikazu; Ogata, Yoshimi; Abe, Shogo; Ando, Takaaki; Ohtsuka, Hiromichi; Kunieda, Tetsuo; Kawamura, Seiichi.

In: Journal of Veterinary Medical Science, Vol. 68, No. 12, 12.2006, p. 1251-1255.

Research output: Contribution to journalArticle

Watanabe, D, Hirano, T, Sugimoto, Y, Ogata, Y, Abe, S, Ando, T, Ohtsuka, H, Kunieda, T & Kawamura, S 2006, 'Carrier rate of Factor XI deficiency in stunted Japanese black cattle', Journal of Veterinary Medical Science, vol. 68, no. 12, pp. 1251-1255. https://doi.org/10.1292/jvms.68.1251
Watanabe D, Hirano T, Sugimoto Y, Ogata Y, Abe S, Ando T et al. Carrier rate of Factor XI deficiency in stunted Japanese black cattle. Journal of Veterinary Medical Science. 2006 Dec;68(12):1251-1255. https://doi.org/10.1292/jvms.68.1251
Watanabe, Daisaku ; Hirano, Takashi ; Sugimoto, Yoshikazu ; Ogata, Yoshimi ; Abe, Shogo ; Ando, Takaaki ; Ohtsuka, Hiromichi ; Kunieda, Tetsuo ; Kawamura, Seiichi. / Carrier rate of Factor XI deficiency in stunted Japanese black cattle. In: Journal of Veterinary Medical Science. 2006 ; Vol. 68, No. 12. pp. 1251-1255.
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