Carrier PNA for shRNA delivery into cells

Mizuki Kitamatsu, Takanori Kubo, Rino Matsuzaki, Tamaki Endoh, Takashi Ohtsuki, Masahiko Sisido

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A peptide nucleic acid (PNA)-cell-penetrating peptide (CPP) conjugate (carrier PNA) was used as 'bridge-builder' to connect a CPP with an shRNA. The carrier PNA successfully formed a hybrid with an shRNA bearing complementary dangling bases and the shRNA was introduced into cells by the carrier PNA, and RNAi was induced by the shRNA. Crown

Original languageEnglish
Pages (from-to)3410-3413
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number13
DOIs
Publication statusPublished - Jul 1 2009

Fingerprint

Peptide Nucleic Acids
Small Interfering RNA
Cell-Penetrating Peptides
Bearings (structural)
RNA Interference
Crowns

Keywords

  • Cell-penetrating peptide
  • Peptide nucleic acid
  • RNA interference

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Kitamatsu, M., Kubo, T., Matsuzaki, R., Endoh, T., Ohtsuki, T., & Sisido, M. (2009). Carrier PNA for shRNA delivery into cells. Bioorganic and Medicinal Chemistry Letters, 19(13), 3410-3413. https://doi.org/10.1016/j.bmcl.2009.05.031

Carrier PNA for shRNA delivery into cells. / Kitamatsu, Mizuki; Kubo, Takanori; Matsuzaki, Rino; Endoh, Tamaki; Ohtsuki, Takashi; Sisido, Masahiko.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 13, 01.07.2009, p. 3410-3413.

Research output: Contribution to journalArticle

Kitamatsu, M, Kubo, T, Matsuzaki, R, Endoh, T, Ohtsuki, T & Sisido, M 2009, 'Carrier PNA for shRNA delivery into cells', Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 13, pp. 3410-3413. https://doi.org/10.1016/j.bmcl.2009.05.031
Kitamatsu, Mizuki ; Kubo, Takanori ; Matsuzaki, Rino ; Endoh, Tamaki ; Ohtsuki, Takashi ; Sisido, Masahiko. / Carrier PNA for shRNA delivery into cells. In: Bioorganic and Medicinal Chemistry Letters. 2009 ; Vol. 19, No. 13. pp. 3410-3413.
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