Carrier PNA for shRNA delivery into cells

Mizuki Kitamatsu; Takanori Kubo; Rino Matsuzaki; Tamaki Endoh; Takashi Ohtsuki; Masahiko Sisido

doi:10.1016/j.bmcl.2009.05.031

Carrier PNA for shRNA delivery into cells

Mizuki Kitamatsu, Takanori Kubo, Rino Matsuzaki, Tamaki Endoh, Takashi Ohtsuki, Masahiko Sisido

Research output: Contribution to journal › Article

10 Citations (Scopus)

Abstract

A peptide nucleic acid (PNA)-cell-penetrating peptide (CPP) conjugate (carrier PNA) was used as 'bridge-builder' to connect a CPP with an shRNA. The carrier PNA successfully formed a hybrid with an shRNA bearing complementary dangling bases and the shRNA was introduced into cells by the carrier PNA, and RNAi was induced by the shRNA. Crown

Original language	English
Pages (from-to)	3410-3413
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	13
DOIs	https://doi.org/10.1016/j.bmcl.2009.05.031
Publication status	Published - Jul 1 2009

Keywords

Cell-penetrating peptide
Peptide nucleic acid
RNA interference

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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Kitamatsu, M., Kubo, T., Matsuzaki, R., Endoh, T., Ohtsuki, T., & Sisido, M. (2009). Carrier PNA for shRNA delivery into cells. Bioorganic and Medicinal Chemistry Letters, 19(13), 3410-3413. https://doi.org/10.1016/j.bmcl.2009.05.031

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AU - Kitamatsu, Mizuki

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AU - Ohtsuki, Takashi

AU - Sisido, Masahiko

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