Carrier PNA for shRNA delivery into cells

Mizuki Kitamatsu; Takanori Kubo; Rino Matsuzaki; Tamaki Endoh; Takashi Ohtsuki; Masahiko Sisido

doi:10.1016/j.bmcl.2009.05.031

Carrier PNA for shRNA delivery into cells

Mizuki Kitamatsu, Takanori Kubo, Rino Matsuzaki, Tamaki Endoh, Takashi Ohtsuki, Masahiko Sisido

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A peptide nucleic acid (PNA)-cell-penetrating peptide (CPP) conjugate (carrier PNA) was used as 'bridge-builder' to connect a CPP with an shRNA. The carrier PNA successfully formed a hybrid with an shRNA bearing complementary dangling bases and the shRNA was introduced into cells by the carrier PNA, and RNAi was induced by the shRNA. Crown

Original language	English
Pages (from-to)	3410-3413
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	13
DOIs	https://doi.org/10.1016/j.bmcl.2009.05.031
Publication status	Published - Jul 1 2009

Keywords

Cell-penetrating peptide
Peptide nucleic acid
RNA interference

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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title = "Carrier PNA for shRNA delivery into cells",

abstract = "A peptide nucleic acid (PNA)-cell-penetrating peptide (CPP) conjugate (carrier PNA) was used as 'bridge-builder' to connect a CPP with an shRNA. The carrier PNA successfully formed a hybrid with an shRNA bearing complementary dangling bases and the shRNA was introduced into cells by the carrier PNA, and RNAi was induced by the shRNA. Crown",

keywords = "Cell-penetrating peptide, Peptide nucleic acid, RNA interference",

author = "Mizuki Kitamatsu and Takanori Kubo and Rino Matsuzaki and Tamaki Endoh and Takashi Ohtsuki and Masahiko Sisido",

note = "Funding Information: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Sciences, and Technology, Japan. ",

year = "2009",

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T1 - Carrier PNA for shRNA delivery into cells

AU - Kitamatsu, Mizuki

AU - Kubo, Takanori

AU - Matsuzaki, Rino

AU - Endoh, Tamaki

AU - Ohtsuki, Takashi

AU - Sisido, Masahiko

N1 - Funding Information: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Sciences, and Technology, Japan.

PY - 2009/7/1

Y1 - 2009/7/1

N2 - A peptide nucleic acid (PNA)-cell-penetrating peptide (CPP) conjugate (carrier PNA) was used as 'bridge-builder' to connect a CPP with an shRNA. The carrier PNA successfully formed a hybrid with an shRNA bearing complementary dangling bases and the shRNA was introduced into cells by the carrier PNA, and RNAi was induced by the shRNA. Crown

AB - A peptide nucleic acid (PNA)-cell-penetrating peptide (CPP) conjugate (carrier PNA) was used as 'bridge-builder' to connect a CPP with an shRNA. The carrier PNA successfully formed a hybrid with an shRNA bearing complementary dangling bases and the shRNA was introduced into cells by the carrier PNA, and RNAi was induced by the shRNA. Crown

KW - Cell-penetrating peptide

KW - Peptide nucleic acid

KW - RNA interference

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