Cariostatic activity of cacao mass extract

T. Ooshima, Y. Osaka, H. Sasaki, K. Osawa, H. Yasuda, Michiyo Nakano

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Chocolate is suspected to contain some caries-inhibitory substances. The cariostatic activity of cacao mass extract (CM), the main component of chocolate, was examined in vitro and in experimental animals. CM showed no detectable effects on the cellular growth and acid production of mutans streptococci. On the other hand, the cell-surface hydrophobicity of mutans streptococci was significantly reduced by the presence of CM. Furthermore, insoluble glucan synthesis by the glucosyltransferases from either Streptococcus mutans MT8148R or Strep. sobrinus 6715 was inhibited by CM, but not significantly. Hence, the sucrose-dependent cell adherence of mutans streptococci was also depressed by CM. Finally, CM in both a 40% sucrose diet and drinking water resulted in reductions of caries development and plaque accumulation in rats infected with Strep sobrinus 6715, but not significantly. These results indicate that cacao mass extract possesses some anticariogenic potential, but its anticaries activity is not strong enough to suppress significantly the cariogenic activity of sucrose. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)805-808
Number of pages4
JournalArchives of Oral Biology
Volume45
Issue number9
DOIs
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Cacao
Streptococcus mutans
Sucrose
Glucosyltransferases
Glucans
Hydrophobic and Hydrophilic Interactions
Drinking Water
Diet
Acids
Growth

Keywords

  • Cacao mass
  • Dental caries
  • Enzyme inhibitors
  • Glucosyltransferase
  • Mutans streptococci

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Ooshima, T., Osaka, Y., Sasaki, H., Osawa, K., Yasuda, H., & Nakano, M. (2000). Cariostatic activity of cacao mass extract. Archives of Oral Biology, 45(9), 805-808. https://doi.org/10.1016/S0003-9969(00)00049-2

Cariostatic activity of cacao mass extract. / Ooshima, T.; Osaka, Y.; Sasaki, H.; Osawa, K.; Yasuda, H.; Nakano, Michiyo.

In: Archives of Oral Biology, Vol. 45, No. 9, 2000, p. 805-808.

Research output: Contribution to journalArticle

Ooshima, T, Osaka, Y, Sasaki, H, Osawa, K, Yasuda, H & Nakano, M 2000, 'Cariostatic activity of cacao mass extract', Archives of Oral Biology, vol. 45, no. 9, pp. 805-808. https://doi.org/10.1016/S0003-9969(00)00049-2
Ooshima, T. ; Osaka, Y. ; Sasaki, H. ; Osawa, K. ; Yasuda, H. ; Nakano, Michiyo. / Cariostatic activity of cacao mass extract. In: Archives of Oral Biology. 2000 ; Vol. 45, No. 9. pp. 805-808.
@article{ad7676bd8ba943499268c80c0dcb94e2,
title = "Cariostatic activity of cacao mass extract",
abstract = "Chocolate is suspected to contain some caries-inhibitory substances. The cariostatic activity of cacao mass extract (CM), the main component of chocolate, was examined in vitro and in experimental animals. CM showed no detectable effects on the cellular growth and acid production of mutans streptococci. On the other hand, the cell-surface hydrophobicity of mutans streptococci was significantly reduced by the presence of CM. Furthermore, insoluble glucan synthesis by the glucosyltransferases from either Streptococcus mutans MT8148R or Strep. sobrinus 6715 was inhibited by CM, but not significantly. Hence, the sucrose-dependent cell adherence of mutans streptococci was also depressed by CM. Finally, CM in both a 40{\%} sucrose diet and drinking water resulted in reductions of caries development and plaque accumulation in rats infected with Strep sobrinus 6715, but not significantly. These results indicate that cacao mass extract possesses some anticariogenic potential, but its anticaries activity is not strong enough to suppress significantly the cariogenic activity of sucrose. (C) 2000 Elsevier Science Ltd.",
keywords = "Cacao mass, Dental caries, Enzyme inhibitors, Glucosyltransferase, Mutans streptococci",
author = "T. Ooshima and Y. Osaka and H. Sasaki and K. Osawa and H. Yasuda and Michiyo Nakano",
year = "2000",
doi = "10.1016/S0003-9969(00)00049-2",
language = "English",
volume = "45",
pages = "805--808",
journal = "Archives of Oral Biology",
issn = "0003-9969",
publisher = "Elsevier Limited",
number = "9",

}

TY - JOUR

T1 - Cariostatic activity of cacao mass extract

AU - Ooshima, T.

AU - Osaka, Y.

AU - Sasaki, H.

AU - Osawa, K.

AU - Yasuda, H.

AU - Nakano, Michiyo

PY - 2000

Y1 - 2000

N2 - Chocolate is suspected to contain some caries-inhibitory substances. The cariostatic activity of cacao mass extract (CM), the main component of chocolate, was examined in vitro and in experimental animals. CM showed no detectable effects on the cellular growth and acid production of mutans streptococci. On the other hand, the cell-surface hydrophobicity of mutans streptococci was significantly reduced by the presence of CM. Furthermore, insoluble glucan synthesis by the glucosyltransferases from either Streptococcus mutans MT8148R or Strep. sobrinus 6715 was inhibited by CM, but not significantly. Hence, the sucrose-dependent cell adherence of mutans streptococci was also depressed by CM. Finally, CM in both a 40% sucrose diet and drinking water resulted in reductions of caries development and plaque accumulation in rats infected with Strep sobrinus 6715, but not significantly. These results indicate that cacao mass extract possesses some anticariogenic potential, but its anticaries activity is not strong enough to suppress significantly the cariogenic activity of sucrose. (C) 2000 Elsevier Science Ltd.

AB - Chocolate is suspected to contain some caries-inhibitory substances. The cariostatic activity of cacao mass extract (CM), the main component of chocolate, was examined in vitro and in experimental animals. CM showed no detectable effects on the cellular growth and acid production of mutans streptococci. On the other hand, the cell-surface hydrophobicity of mutans streptococci was significantly reduced by the presence of CM. Furthermore, insoluble glucan synthesis by the glucosyltransferases from either Streptococcus mutans MT8148R or Strep. sobrinus 6715 was inhibited by CM, but not significantly. Hence, the sucrose-dependent cell adherence of mutans streptococci was also depressed by CM. Finally, CM in both a 40% sucrose diet and drinking water resulted in reductions of caries development and plaque accumulation in rats infected with Strep sobrinus 6715, but not significantly. These results indicate that cacao mass extract possesses some anticariogenic potential, but its anticaries activity is not strong enough to suppress significantly the cariogenic activity of sucrose. (C) 2000 Elsevier Science Ltd.

KW - Cacao mass

KW - Dental caries

KW - Enzyme inhibitors

KW - Glucosyltransferase

KW - Mutans streptococci

UR - http://www.scopus.com/inward/record.url?scp=0033886115&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033886115&partnerID=8YFLogxK

U2 - 10.1016/S0003-9969(00)00049-2

DO - 10.1016/S0003-9969(00)00049-2

M3 - Article

VL - 45

SP - 805

EP - 808

JO - Archives of Oral Biology

JF - Archives of Oral Biology

SN - 0003-9969

IS - 9

ER -