Abstract
Accumulated evidence has strongly suggested that the long-term effects of periodontal diseases can be linked to more serious systemic conditions such as cardiovascular diseases, diabetes, and complications of pregnancy. Especially, a prevalence of coronary heart disease was found to be significantly increased in patients with periodontitis after adjusting for risk factors such as smoking, diabetes, alcohol intake, obesity, and blood pressure. Furthermore, various studies have shown that Porphyromonas gingivalis, a major periodontal pathogen, is able to exacerbate atherosclerosis following oral-hematogenous spread due to the bacteremia. By P. gingivalis, endothelial cells activate and upregulate various adhesion molecules, thus increasing the likelihood of macrophage diapedesis and subsequent conversion to foam cells thus furthering athroma progression. These findings likely indicate the tight relationship between periodontitis/periodontal pathogens and cardiovascular diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 43-48 |
| Number of pages | 6 |
| Journal | Clinical calcium |
| Volume | 22 |
| Issue number | 1 |
| Publication status | Published - Jan 2012 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
[Cardiovascular diseases and periodontal diseases]. / Amano, Atsuo; Inaba, Hiroaki.
In: Clinical calcium, Vol. 22, No. 1, 01.2012, p. 43-48.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - [Cardiovascular diseases and periodontal diseases].
AU - Amano, Atsuo
AU - Inaba, Hiroaki
PY - 2012/1
Y1 - 2012/1
N2 - Accumulated evidence has strongly suggested that the long-term effects of periodontal diseases can be linked to more serious systemic conditions such as cardiovascular diseases, diabetes, and complications of pregnancy. Especially, a prevalence of coronary heart disease was found to be significantly increased in patients with periodontitis after adjusting for risk factors such as smoking, diabetes, alcohol intake, obesity, and blood pressure. Furthermore, various studies have shown that Porphyromonas gingivalis, a major periodontal pathogen, is able to exacerbate atherosclerosis following oral-hematogenous spread due to the bacteremia. By P. gingivalis, endothelial cells activate and upregulate various adhesion molecules, thus increasing the likelihood of macrophage diapedesis and subsequent conversion to foam cells thus furthering athroma progression. These findings likely indicate the tight relationship between periodontitis/periodontal pathogens and cardiovascular diseases.
AB - Accumulated evidence has strongly suggested that the long-term effects of periodontal diseases can be linked to more serious systemic conditions such as cardiovascular diseases, diabetes, and complications of pregnancy. Especially, a prevalence of coronary heart disease was found to be significantly increased in patients with periodontitis after adjusting for risk factors such as smoking, diabetes, alcohol intake, obesity, and blood pressure. Furthermore, various studies have shown that Porphyromonas gingivalis, a major periodontal pathogen, is able to exacerbate atherosclerosis following oral-hematogenous spread due to the bacteremia. By P. gingivalis, endothelial cells activate and upregulate various adhesion molecules, thus increasing the likelihood of macrophage diapedesis and subsequent conversion to foam cells thus furthering athroma progression. These findings likely indicate the tight relationship between periodontitis/periodontal pathogens and cardiovascular diseases.
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M3 - Review article
C2 - 22201098
AN - SCOPUS:84859913317
VL - 22
SP - 43
EP - 48
JO - Clinical calcium
JF - Clinical calcium
SN - 0917-5857
IS - 1
ER -