Cardio-ankle vascular index is independently associated with the severity of coronary atherosclerosis and left ventricular function in patients with Ischemic heart disease

Toru Miyoshi, Masayuki Doi, Satoshi Hirohata, Kosuke Sakane, Shigeshi Kamikawa, Tomoki Kitawaki, Youko Kaji, Kengo Fukushima Kusano, Yoshifumi Ninomiya, Shozo Kusachi

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)

Abstract

Aim: The cardio-ankle vascular index (CAVI) has been proposed as a new noninvasive marker of arterial stiffness independent of blood pressure. We investigated the association of the CAVI with coronary atherosclerosis and left ventricular (LV) systolic and diastolic function in patients with ischemic heart disease (IHD). Methods: A total of 206 consecutive subjects undergoing coronary angiography were enrolled. CAVI measurement and echocardiography were performed simultaneously. Patients having significant coronary stenosis were classified into the IHD group. Results: CAVI in the IHD group (n 133) was significantly higher than in the non-IHD group (n 73) (9.1±1.3 vs. 8.7±1.2, p 0.02). In all IHD patients, CAVI was negatively correlated with LV ejection fraction (LVEF) (r=-0.31, p<0.01), LV mass index (r 0.24, p<0.01) and angiographic scores of coronary atherosclerosis. Stepwise regression analysis revealed that CAVI was independently associated with LVEF, along with a history of myocardial infarction, LV mass index, and left atrial diameter in all IHD patients (p<0.01). In the sub-analysis of IHD patients with preserved LVEF, CAVI was correlated with echocardiographic parameters regarding LV diastolic function. Multivariate analysis demonstrated that the increased CAVI was significantly associated with LV diastolic dysfunction in patients with preserved LVEF. Conclusion: CAVI, a new parameter of aortic stiffness, was independently associated with LV systolic and diastolic function as well as coronary artery disease in IHD patients.

Original languageEnglish
Pages (from-to)249-258
Number of pages10
JournalJournal of atherosclerosis and thrombosis
Volume17
Issue number3
DOIs
Publication statusPublished - 2010

Keywords

  • Arterial stiffness
  • Cardio-ankle vascular index
  • Ischemic heart disease
  • Left ventricular function

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

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