Carcinoma infection and immune systems of Ehrlich ascites carcinoma-bearing mice treated with structurally similar sulfonium compounds

Kenji Nakajima, Yoshiki Nakajima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effects of intraperitoneal administration of dimethylsulfonioacetate (DMSA), dimethlsulfoniopropionate (DMSP), and methylmethionine (MeMet) solutions (10 mM each) on the body weights and the hematological parameters (red and white blood cells) of Ehrlich ascites carcinoma (EAC)-bearing mice were examined for up to 10d. Body weights significantly increased in the EAC-bearing mice treated with and without MeMet in contrast to those with DMSA and DMSP. This increase was attributed to the increased amounts of ascitic fluid. EAC-bearing mice with and without MeMet both showed abnormal values of hematological parameters, while those with DMSA and DMSP exhibited almost normal levels on the 10th day.

Original languageEnglish
Pages (from-to)808-811
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume75
Issue number4
DOIs
Publication statusPublished - May 16 2011

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Keywords

  • Dimethylsulfonioacetate
  • Dimethylsulfoniopropionate
  • Ehrlich ascites carcinoma
  • Methylmethionine
  • Red and white blood cells

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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