Carbonic anhydrase inhibitors from the pericarps of Punica granatum L.

H. Satomi, K. Umemura, A. Ueno, Tsutomu Hatano, T. Okuda, T. Noro

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Abstract

Seven highly active inhibitors against carbonic anhydrase (CA, EC 4.2.1.1), punicalin (2), punicalagin (3), granatin B (5), gallagyldilactone (7), easuarinin (8), pedunculagin (9) and tellimagrandin 1 (10), and four weakly active inhibitors, gallic acid (1), granatin A (4), corilagin (6) and ellagic acid (11), were isolated from the pericarps of Punica granatum L. (Punicaceae). They are ellagitannins. The type of inhibition by 3 and 7 using p-nitrophenyl acetate as a substrate, is noncompetitive. The structure- activity relationship of inhibitory effects on CA is discussed.

Original languageEnglish
Pages (from-to)787-790
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume16
Issue number8
Publication statusPublished - 1993

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ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Satomi, H., Umemura, K., Ueno, A., Hatano, T., Okuda, T., & Noro, T. (1993). Carbonic anhydrase inhibitors from the pericarps of Punica granatum L. Biological and Pharmaceutical Bulletin, 16(8), 787-790.