Carbonic Anhydrase Inhibitors from the Pericarps of Punica granatum L

Hayato Satomi, Keijirou Umemura, Akira Ueno, Tsutomu Hatano, Takuo Okuda, Tadataka Noro

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Seven highly active inhibitors against carbonic anhydrase (CA, EC 4.2.1.1), punicalin (2), punicalagin (3), granatin B (5), gallagyldilactone (7), casuarinin (8), pedunculagin (9) and tellimagrandin I (10), and four weakly active inhibitors, gallic acid (1), granatin A (4), corilagin (6) and ellagic acid (11), were isolated from the pericarps of Punica granatum L. (Punicaceae). They are ellagitannins. The type of inhibition by 3 and 7 using p-nitrophenyl acetate as a substrate, is noncompetitive. The structure-activity relationship of inhibitory effects on CA is discussed.

Original languageEnglish
Pages (from-to)787-790
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume16
Issue number8
DOIs
Publication statusPublished - Jan 1 1993

Keywords

  • Punica granatum
  • carbonic anhydrase
  • gallagyldilactone
  • inhibitor
  • noncompetitive inhibition
  • p-nitrophenyl acetate

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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