Seven highly active inhibitors against carbonic anhydrase (CA, EC 184.108.40.206), punicalin (2), punicalagin (3), granatin B (5), gallagyldilactone (7), easuarinin (8), pedunculagin (9) and tellimagrandin 1 (10), and four weakly active inhibitors, gallic acid (1), granatin A (4), corilagin (6) and ellagic acid (11), were isolated from the pericarps of Punica granatum L. (Punicaceae). They are ellagitannins. The type of inhibition by 3 and 7 using p-nitrophenyl acetate as a substrate, is noncompetitive. The structure- activity relationship of inhibitory effects on CA is discussed.
|Number of pages||4|
|Journal||Biological and Pharmaceutical Bulletin|
|Publication status||Published - 1993|
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)