TY - JOUR
T1 - Carbonic Anhydrase Inhibitors from the Pericarps of Punica granatum L
AU - Satomi, Hayato
AU - Umemura, Keijirou
AU - Ueno, Akira
AU - Hatano, Tsutomu
AU - Okuda, Takuo
AU - Noro, Tadataka
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1993
Y1 - 1993
N2 - Seven highly active inhibitors against carbonic anhydrase (CA, EC 4.2.1.1), punicalin (2), punicalagin (3), granatin B (5), gallagyldilactone (7), casuarinin (8), pedunculagin (9) and tellimagrandin I (10), and four weakly active inhibitors, gallic acid (1), granatin A (4), corilagin (6) and ellagic acid (11), were isolated from the pericarps of Punica granatum L. (Punicaceae). They are ellagitannins. The type of inhibition by 3 and 7 using p-nitrophenyl acetate as a substrate, is noncompetitive. The structure-activity relationship of inhibitory effects on CA is discussed.
AB - Seven highly active inhibitors against carbonic anhydrase (CA, EC 4.2.1.1), punicalin (2), punicalagin (3), granatin B (5), gallagyldilactone (7), casuarinin (8), pedunculagin (9) and tellimagrandin I (10), and four weakly active inhibitors, gallic acid (1), granatin A (4), corilagin (6) and ellagic acid (11), were isolated from the pericarps of Punica granatum L. (Punicaceae). They are ellagitannins. The type of inhibition by 3 and 7 using p-nitrophenyl acetate as a substrate, is noncompetitive. The structure-activity relationship of inhibitory effects on CA is discussed.
KW - Punica granatum
KW - carbonic anhydrase
KW - gallagyldilactone
KW - inhibitor
KW - noncompetitive inhibition
KW - p-nitrophenyl acetate
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U2 - 10.1248/bpb.16.787
DO - 10.1248/bpb.16.787
M3 - Article
C2 - 8220326
AN - SCOPUS:0027374461
SN - 0918-6158
VL - 16
SP - 787
EP - 790
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
IS - 8
ER -