Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma

and the Working Group for Carbon Ion Radiotherapy for Bone and Soft Tissue Sarcomas

doi:10.1002/cam4.1679

Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma

and the Working Group for Carbon Ion Radiotherapy for Bone and Soft Tissue Sarcomas

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Carbon ion radiotherapy is known for its high-precision dose distribution and high biological effectiveness. We evaluated the results of carbon ion radiotherapy in 128 patients with unresectable localized axial soft tissue sarcoma at a single institution. The patients’ median age was 54 years, and the median follow-up period was 49.4 (range 6.4-146.4) months. The median tumor volume was 356 cm³. The 5-year local control, overall survival, and disease-free survival rates were 65%, 46%, and 39%, respectively. In the univariate analysis, tumor volume, local control, and incidences of metastases were significantly related to overall survival. In the multivariate analysis, tumor volume and local control were significantly related to overall survival. We did not find any factors related to local control. Five patients required surgical intervention because of adverse events in the bones. Carbon ion radiotherapy may be a treatment option for unresectable axial soft tissue sarcoma.

Original language	English
Pages (from-to)	4308-4314
Number of pages	7
Journal	Cancer medicine
Volume	7
Issue number	9
DOIs	https://doi.org/10.1002/cam4.1679
Publication status	Published - Sep 2018

Keywords

carbon ion radiotherapy
charged particle therapy
radiotherapy
soft tissue sarcoma

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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title = "Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma",

abstract = "Carbon ion radiotherapy is known for its high-precision dose distribution and high biological effectiveness. We evaluated the results of carbon ion radiotherapy in 128 patients with unresectable localized axial soft tissue sarcoma at a single institution. The patients{\textquoteright} median age was 54 years, and the median follow-up period was 49.4 (range 6.4-146.4) months. The median tumor volume was 356 cm3. The 5-year local control, overall survival, and disease-free survival rates were 65%, 46%, and 39%, respectively. In the univariate analysis, tumor volume, local control, and incidences of metastases were significantly related to overall survival. In the multivariate analysis, tumor volume and local control were significantly related to overall survival. We did not find any factors related to local control. Five patients required surgical intervention because of adverse events in the bones. Carbon ion radiotherapy may be a treatment option for unresectable axial soft tissue sarcoma.",

keywords = "carbon ion radiotherapy, charged particle therapy, radiotherapy, soft tissue sarcoma",

author = "{and the Working Group for Carbon Ion Radiotherapy for Bone and Soft Tissue Sarcomas} and Reiko Imai and Tadashi Kamada and Nobuhito Araki and Satoshi Abe and Yukihide Iwamoto and Toshifumi Ozaki and Hirokazu Chuman and Hiroaki Hiraga and Toru Hiruma and Noriaki Kameda and Chihiro Kanehira and Mitsunori Kaya and Rikuo Machinami and Akihiko Matsumine and Seiichi Matsumoto and Hideo Morioka and Yoshihiro Nishida and Kazuhisa Takahashi and Masazumi Tsuneyoshi and Takehiko Yamaguchi and Tsukasa Yonemoto",

year = "2018",

month = sep,

doi = "10.1002/cam4.1679",

language = "English",

volume = "7",

pages = "4308--4314",

journal = "Cancer Medicine",

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T1 - Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma

AU - and the Working Group for Carbon Ion Radiotherapy for Bone and Soft Tissue Sarcomas

AU - Imai, Reiko

AU - Kamada, Tadashi

AU - Araki, Nobuhito

AU - Abe, Satoshi

AU - Iwamoto, Yukihide

AU - Ozaki, Toshifumi

AU - Chuman, Hirokazu

AU - Hiraga, Hiroaki

AU - Hiruma, Toru

AU - Kameda, Noriaki

AU - Kanehira, Chihiro

AU - Kaya, Mitsunori

AU - Machinami, Rikuo

AU - Matsumine, Akihiko

AU - Matsumoto, Seiichi

AU - Morioka, Hideo

AU - Nishida, Yoshihiro

AU - Takahashi, Kazuhisa

AU - Tsuneyoshi, Masazumi

AU - Yamaguchi, Takehiko

AU - Yonemoto, Tsukasa

PY - 2018/9

Y1 - 2018/9

N2 - Carbon ion radiotherapy is known for its high-precision dose distribution and high biological effectiveness. We evaluated the results of carbon ion radiotherapy in 128 patients with unresectable localized axial soft tissue sarcoma at a single institution. The patients’ median age was 54 years, and the median follow-up period was 49.4 (range 6.4-146.4) months. The median tumor volume was 356 cm3. The 5-year local control, overall survival, and disease-free survival rates were 65%, 46%, and 39%, respectively. In the univariate analysis, tumor volume, local control, and incidences of metastases were significantly related to overall survival. In the multivariate analysis, tumor volume and local control were significantly related to overall survival. We did not find any factors related to local control. Five patients required surgical intervention because of adverse events in the bones. Carbon ion radiotherapy may be a treatment option for unresectable axial soft tissue sarcoma.

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