Carbazochrome attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats

Toshiaki Sendo, Takeshi Goromaru, Keisei Aki, Naoko Sakai, Yoshinori Itoh, Ryozo Oishi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The effects of carbazochrome sodium sulfonate (AC-17), a capillary stabilizer, on pulmonary edema and dysfunction induced by ioxaglate, an ionic radiographic contrast medium, were evaluated in rats. The pulmonary edema was evaluated by the extravasation of intravenously injected Evans blue into lung tissues, while pulmonary dysfunction was determined by monitoring blood gasses including pO2. Ioxaglate (4 g I/kg, i.v.) caused a marked increase in vascular permeability and a decrease in arterial pO2. AC-17 reversed the ioxaglate-induced vascular hyperpermeability in a dose-dependent manner. In addition, AC-17 (10 mg/kg) significantly inhibited the decrease in arterial pO2. In isolated rat pulmonary mast cells, ioxaglate markedly enhanced the histamine release, which was not affected by AC-17. On the other hand, AC-17 did significantly blocked the hyperpermeability induced in cultured bovine endothelial cells by tryptase, thrombin and proteinase-activated receptor-2 agonist peptide (SLIGKV-NH2). These findings suggest that AC-17 blocks radiographic contrast medium-induced pulmonary dysfunction by maintaining the endothelial barrier function. Thus, the compound is potentially useful for the prophylaxis of contrast media-induced acute pulmonary adverse events during angiography.

Original languageEnglish
Pages (from-to)203-208
Number of pages6
JournalEuropean Journal of Pharmacology
Volume450
Issue number2
DOIs
Publication statusPublished - Aug 23 2002
Externally publishedYes

Keywords

  • Carbazochrome
  • Endothelial barrier function
  • Evans blue
  • Pulmonary edema
  • Radiographic contrast media
  • Vascular permeability

ASJC Scopus subject areas

  • Pharmacology

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