Capsaicin pretreatment attenuates LPS-induced hypothermia through TRPV1-independent mechanisms in chicken

Hideki Nikami, Motamed Elsayed Mahmoud, Yasutake Shimizu, Takahiko Shiina, Haruko Hirayama, Momoe Iwami, Reem Mahmoud Dosoky, Moustafa Mohamed Ahmed, Tadashi Takewaki

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15 Citations (Scopus)

Abstract

It has been demonstrated that chicken TRPV1 (transient receptor potential vanilloid of subtype-1) is insensitive to capsaicin (CAP), and therefore, a chicken model is suitable to analyze the CAP-sensitive TRPV1-independent pathway. We elucidated here the possible involvement of the pathway in hypothermia induced by bacterial endotoxin (lipopolysaccharide, LPS) in chickens. Chicks were pretreated with CAP (10 mg/kg, iv) at 1, 2 and 3 days of age to desensitize them towards the CAP-sensitive pathway. An intravenous injection of LPS in 4-day-old chicks caused progressive hypothermia, ending with collapse and 78% mortality within 12 h after injection. The CAP pretreatment rescued the LPS-induced endotoxin shock and hypothermia in chicks. LPS-induced iNOS expression as well as NO production in liver and lung was suppressed by CAP pretreatment. CAP pretreatment also attenuated hypothermia due to exposure of chicks to cold ambient temperature. These findings suggest that a CAP-sensitive TRPV1-independent pathway may be involved in pathophysiological hypothermic reactions through the mediation of NO in chickens.

Original languageEnglish
Pages (from-to)1191-1195
Number of pages5
JournalLife Sciences
Volume82
Issue number23-24
DOIs
Publication statusPublished - Jun 6 2008

Keywords

  • Capsaicin
  • Chicken
  • Cold ambient temperature
  • LPS
  • TRPV1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Nikami, H., Mahmoud, M. E., Shimizu, Y., Shiina, T., Hirayama, H., Iwami, M., Dosoky, R. M., Ahmed, M. M., & Takewaki, T. (2008). Capsaicin pretreatment attenuates LPS-induced hypothermia through TRPV1-independent mechanisms in chicken. Life Sciences, 82(23-24), 1191-1195. https://doi.org/10.1016/j.lfs.2008.04.003