Cannabidiol prevents infarction via the non-CBI cannabinoid receptor mechanism

Kazuhide Hayakawa, Kenichi Mishima, Koji Abe, Nobuyoshi Hasebe, Fumie Takamatsu, Hiromi Yasuda, Tomoaki Ikeda, Keiichiro Inui, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwara

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Cannabidiol, a non-psychoactive constituent of cannabis, has been reported as a neuroprotectant. Cannabidiol and Δ 9-tetrahydrocannabinol, the primary psychoactive constituent of cannabis, significantly decreased the infarct volume at 4 h in the mouse middle cerebral artery occlusion model. The neuroprotective effects of Δ 9-tetrahydrocannabinol but not cannabidiol were inhibited by SRI41716, a cannabinoid CBI receptor antagonist, and were abolished by warming of the animals to the levels observed in the controls. Δ 9-Tetrahydrocannabinol significantly decreased the rectal temperature, and the hypothermic effect was inhibited by SRI41716. These results surely show that the neuroprotective effect of Δ 9- tetrahydrocannabinol are via a CBI receptor and temperature-dependent mechanisms whereas the neuroprotective effects of cannabidiol are independent of CBI blockade and of hypothermia.

Original languageEnglish
Pages (from-to)2381-2385
Number of pages5
JournalNeuroReport
Volume15
Issue number15
DOIs
Publication statusPublished - Oct 25 2004
Externally publishedYes

Fingerprint

Cannabidiol
Cannabinoid Receptors
Dronabinol
Neuroprotective Agents
Infarction
Cannabis
Cannabinoid Receptor Antagonists
Temperature
Middle Cerebral Artery Infarction
Hypothermia

Keywords

  • Δ -Tetrahydrocannabinol
  • Cannabidiol
  • CBI receptor
  • Hypothermia
  • Middle cerebral artery occlusion
  • Rectal temperature

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hayakawa, K., Mishima, K., Abe, K., Hasebe, N., Takamatsu, F., Yasuda, H., ... Fujiwara, M. (2004). Cannabidiol prevents infarction via the non-CBI cannabinoid receptor mechanism. NeuroReport, 15(15), 2381-2385. https://doi.org/10.1097/00001756-200410250-00016

Cannabidiol prevents infarction via the non-CBI cannabinoid receptor mechanism. / Hayakawa, Kazuhide; Mishima, Kenichi; Abe, Koji; Hasebe, Nobuyoshi; Takamatsu, Fumie; Yasuda, Hiromi; Ikeda, Tomoaki; Inui, Keiichiro; Egashira, Nobuaki; Iwasaki, Katsunori; Fujiwara, Michihiro.

In: NeuroReport, Vol. 15, No. 15, 25.10.2004, p. 2381-2385.

Research output: Contribution to journalArticle

Hayakawa, K, Mishima, K, Abe, K, Hasebe, N, Takamatsu, F, Yasuda, H, Ikeda, T, Inui, K, Egashira, N, Iwasaki, K & Fujiwara, M 2004, 'Cannabidiol prevents infarction via the non-CBI cannabinoid receptor mechanism', NeuroReport, vol. 15, no. 15, pp. 2381-2385. https://doi.org/10.1097/00001756-200410250-00016
Hayakawa K, Mishima K, Abe K, Hasebe N, Takamatsu F, Yasuda H et al. Cannabidiol prevents infarction via the non-CBI cannabinoid receptor mechanism. NeuroReport. 2004 Oct 25;15(15):2381-2385. https://doi.org/10.1097/00001756-200410250-00016
Hayakawa, Kazuhide ; Mishima, Kenichi ; Abe, Koji ; Hasebe, Nobuyoshi ; Takamatsu, Fumie ; Yasuda, Hiromi ; Ikeda, Tomoaki ; Inui, Keiichiro ; Egashira, Nobuaki ; Iwasaki, Katsunori ; Fujiwara, Michihiro. / Cannabidiol prevents infarction via the non-CBI cannabinoid receptor mechanism. In: NeuroReport. 2004 ; Vol. 15, No. 15. pp. 2381-2385.
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