Cannabidiol prevents infarction via the non-CBI cannabinoid receptor mechanism

Kazuhide Hayakawa, Kenichi Mishima, Kohji Abe, Nobuyoshi Hasebe, Fumie Takamatsu, Hiromi Yasuda, Tomoaki Ikeda, Keiichiro Inui, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwara

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Abstract

Cannabidiol, a non-psychoactive constituent of cannabis, has been reported as a neuroprotectant. Cannabidiol and Δ 9-tetrahydrocannabinol, the primary psychoactive constituent of cannabis, significantly decreased the infarct volume at 4 h in the mouse middle cerebral artery occlusion model. The neuroprotective effects of Δ 9-tetrahydrocannabinol but not cannabidiol were inhibited by SRI41716, a cannabinoid CBI receptor antagonist, and were abolished by warming of the animals to the levels observed in the controls. Δ 9-Tetrahydrocannabinol significantly decreased the rectal temperature, and the hypothermic effect was inhibited by SRI41716. These results surely show that the neuroprotective effect of Δ 9- tetrahydrocannabinol are via a CBI receptor and temperature-dependent mechanisms whereas the neuroprotective effects of cannabidiol are independent of CBI blockade and of hypothermia.

Original languageEnglish
Pages (from-to)2381-2385
Number of pages5
JournalNeuroReport
Volume15
Issue number15
DOIs
Publication statusPublished - Oct 25 2004

Keywords

  • CBI receptor
  • Cannabidiol
  • Hypothermia
  • Middle cerebral artery occlusion
  • Rectal temperature
  • Δ -Tetrahydrocannabinol

ASJC Scopus subject areas

  • Neuroscience(all)

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    Hayakawa, K., Mishima, K., Abe, K., Hasebe, N., Takamatsu, F., Yasuda, H., Ikeda, T., Inui, K., Egashira, N., Iwasaki, K., & Fujiwara, M. (2004). Cannabidiol prevents infarction via the non-CBI cannabinoid receptor mechanism. NeuroReport, 15(15), 2381-2385. https://doi.org/10.1097/00001756-200410250-00016