Cancer/testis antigens: A prospective reagent as diagnostic and immunotherapeutic targets for squamous cell carcinoma of the head and neck

Shohei Domae, Toshiro Ono, Akira Sasaki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Numerous tumor antigens have so far been identified from various tumors using the serological identification of antigens by recombinant expression cloning (SEREX) method. Among them, cancer/testis (CT) antigens are considered promising target molecules for immunotherapy for patients with various cancers. We performed several SEREX analyses of various cancers to identify CT antigens, including gastric adenocarcinoma, lung adenocarcinoma, and colon cancer, and consequently identified additional CT antigens, such as XAGE-1, CCDC62-2, GKAP1, and TEKT5. However, although SEREX analysis of squamous cell carcinoma of the head and neck (HNSCC) has been performed several times, only a few CT or HNSCC specific antigens have yet been isolated. Compared with other tumors, a small number of studies have been reported on the antigen proteins specific to HNSCC. We here reported the expression of selected CT antigens and their immunogenicity in patients with HNSCC. The results obtained suggested that CCDC62-2, GKAP1, and TEKT5 are immunogenic in HNSCC and also demonstrated their potencies as diagnostic markers for patients with HNSCC in combination with other CT antigens such as NY-ESO-1, MAGE-A3, and MAGE-A4.

Original languageEnglish
Pages (from-to)91-99
Number of pages9
JournalJapanese Dental Science Review
Volume50
Issue number4
DOIs
Publication statusPublished - Nov 1 2014

Fingerprint

Testicular Neoplasms
Antigens
Neoplasms
Carcinoma, squamous cell of head and neck
Neoplasm Antigens
Immunotherapy
Colonic Neoplasms
Organism Cloning
Lung Neoplasms
Stomach

Keywords

  • Antibody response
  • Cancer/testis antigen
  • SEREX
  • Squamous cell carcinoma of the head and neck

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Cancer/testis antigens : A prospective reagent as diagnostic and immunotherapeutic targets for squamous cell carcinoma of the head and neck. / Domae, Shohei; Ono, Toshiro; Sasaki, Akira.

In: Japanese Dental Science Review, Vol. 50, No. 4, 01.11.2014, p. 91-99.

Research output: Contribution to journalArticle

@article{1cc62d62ad934be19090a57de8aa4d49,
title = "Cancer/testis antigens: A prospective reagent as diagnostic and immunotherapeutic targets for squamous cell carcinoma of the head and neck",
abstract = "Numerous tumor antigens have so far been identified from various tumors using the serological identification of antigens by recombinant expression cloning (SEREX) method. Among them, cancer/testis (CT) antigens are considered promising target molecules for immunotherapy for patients with various cancers. We performed several SEREX analyses of various cancers to identify CT antigens, including gastric adenocarcinoma, lung adenocarcinoma, and colon cancer, and consequently identified additional CT antigens, such as XAGE-1, CCDC62-2, GKAP1, and TEKT5. However, although SEREX analysis of squamous cell carcinoma of the head and neck (HNSCC) has been performed several times, only a few CT or HNSCC specific antigens have yet been isolated. Compared with other tumors, a small number of studies have been reported on the antigen proteins specific to HNSCC. We here reported the expression of selected CT antigens and their immunogenicity in patients with HNSCC. The results obtained suggested that CCDC62-2, GKAP1, and TEKT5 are immunogenic in HNSCC and also demonstrated their potencies as diagnostic markers for patients with HNSCC in combination with other CT antigens such as NY-ESO-1, MAGE-A3, and MAGE-A4.",
keywords = "Antibody response, Cancer/testis antigen, SEREX, Squamous cell carcinoma of the head and neck",
author = "Shohei Domae and Toshiro Ono and Akira Sasaki",
year = "2014",
month = "11",
day = "1",
doi = "10.1016/j.jdsr.2014.06.001",
language = "English",
volume = "50",
pages = "91--99",
journal = "Japanese Dental Science Review",
issn = "1882-7616",
publisher = "Elsevier BV",
number = "4",

}

TY - JOUR

T1 - Cancer/testis antigens

T2 - A prospective reagent as diagnostic and immunotherapeutic targets for squamous cell carcinoma of the head and neck

AU - Domae, Shohei

AU - Ono, Toshiro

AU - Sasaki, Akira

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Numerous tumor antigens have so far been identified from various tumors using the serological identification of antigens by recombinant expression cloning (SEREX) method. Among them, cancer/testis (CT) antigens are considered promising target molecules for immunotherapy for patients with various cancers. We performed several SEREX analyses of various cancers to identify CT antigens, including gastric adenocarcinoma, lung adenocarcinoma, and colon cancer, and consequently identified additional CT antigens, such as XAGE-1, CCDC62-2, GKAP1, and TEKT5. However, although SEREX analysis of squamous cell carcinoma of the head and neck (HNSCC) has been performed several times, only a few CT or HNSCC specific antigens have yet been isolated. Compared with other tumors, a small number of studies have been reported on the antigen proteins specific to HNSCC. We here reported the expression of selected CT antigens and their immunogenicity in patients with HNSCC. The results obtained suggested that CCDC62-2, GKAP1, and TEKT5 are immunogenic in HNSCC and also demonstrated their potencies as diagnostic markers for patients with HNSCC in combination with other CT antigens such as NY-ESO-1, MAGE-A3, and MAGE-A4.

AB - Numerous tumor antigens have so far been identified from various tumors using the serological identification of antigens by recombinant expression cloning (SEREX) method. Among them, cancer/testis (CT) antigens are considered promising target molecules for immunotherapy for patients with various cancers. We performed several SEREX analyses of various cancers to identify CT antigens, including gastric adenocarcinoma, lung adenocarcinoma, and colon cancer, and consequently identified additional CT antigens, such as XAGE-1, CCDC62-2, GKAP1, and TEKT5. However, although SEREX analysis of squamous cell carcinoma of the head and neck (HNSCC) has been performed several times, only a few CT or HNSCC specific antigens have yet been isolated. Compared with other tumors, a small number of studies have been reported on the antigen proteins specific to HNSCC. We here reported the expression of selected CT antigens and their immunogenicity in patients with HNSCC. The results obtained suggested that CCDC62-2, GKAP1, and TEKT5 are immunogenic in HNSCC and also demonstrated their potencies as diagnostic markers for patients with HNSCC in combination with other CT antigens such as NY-ESO-1, MAGE-A3, and MAGE-A4.

KW - Antibody response

KW - Cancer/testis antigen

KW - SEREX

KW - Squamous cell carcinoma of the head and neck

UR - http://www.scopus.com/inward/record.url?scp=84908552807&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908552807&partnerID=8YFLogxK

U2 - 10.1016/j.jdsr.2014.06.001

DO - 10.1016/j.jdsr.2014.06.001

M3 - Article

AN - SCOPUS:84908552807

VL - 50

SP - 91

EP - 99

JO - Japanese Dental Science Review

JF - Japanese Dental Science Review

SN - 1882-7616

IS - 4

ER -