Cancer of unknown primary site: A review of 28 cases and the efficacy of cisplatin/docetaxel therapy at a Single Institute in Japan

Hisakazu Nishimori, Shunji Takahashi, Katsuyuki Kiura, Daisuke Ennishi, Takayuki Kobayashi, Koji Sano, Eiji Shinozaki, Masahiro Yokoyama, Yuko Mishima, Yasuhito Terui, Keisho Chin, Nobuyuki Mizunuma, Yoshinori Ito, Seiichiro Nishimura, Kengo Takeuchri, Yuichi Ishikawa, Masahiko Oguchi, Mitsune Tanimoto, Kiyohiko Hatake

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We evaluated the efficacy and toxicity of cisplatin/docetaxel (CDDP/TXT) chemotherapy and identified prognostic factors in Japanese patients with cancer of unknown primary site (CUP). Twenty-eight consecutive patients seen at a single institute were reviewed retrospectively. Sixteen patients were treated with TXT 80mg/m2, followed by CDDP 75mg/m2. The overall response rate to CDDP/TXT treatment was 62.5%, with a median survival time (MST) of 22.7 months. Common adverse reactions were myelosuppression and hyponatremia. The MST of all 28 patients with CUP was 8.3 months, and the 1-year overall survival rate was 45.6%. Univariate analysis identified 5 prognostic factors:performance status, liver involvement, bone involvement, pleural involvement, and lymph node involvement. In conclusion, CDDP/TXT chemotherapy is effective with tolerable toxicity in patients with CUP. Japanese patients with CUP might be chemosensitive and may survive longer.

Original languageEnglish
Pages (from-to)285-291
Number of pages7
JournalActa medica Okayama
Volume64
Issue number5
Publication statusPublished - 2010

Keywords

  • Cancer of unknown primary site (CUP)
  • Cisplatin
  • Docetaxel
  • Prognosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Cancer of unknown primary site: A review of 28 cases and the efficacy of cisplatin/docetaxel therapy at a Single Institute in Japan'. Together they form a unique fingerprint.

  • Cite this

    Nishimori, H., Takahashi, S., Kiura, K., Ennishi, D., Kobayashi, T., Sano, K., Shinozaki, E., Yokoyama, M., Mishima, Y., Terui, Y., Chin, K., Mizunuma, N., Ito, Y., Nishimura, S., Takeuchri, K., Ishikawa, Y., Oguchi, M., Tanimoto, M., & Hatake, K. (2010). Cancer of unknown primary site: A review of 28 cases and the efficacy of cisplatin/docetaxel therapy at a Single Institute in Japan. Acta medica Okayama, 64(5), 285-291.