Abstract
Plasma 5-hydroxytryptamine (serotonin), tryptophan, neopterin and cortisol levels were measured in patients with depressive cancer cachexia and in healthy controls during the same time period. Patients with advanced cancers had significantly raised neopterin, a marker of endogenous gamma-interferon (IFN-γ) production, and cortisol values, but decreased serotonin and tryptophan levels. Much work has been done to elucidate the possible role of serotonin in depressive states. IFN-γ induces a high level of indoleamine dioxygenase (IDO), a tryptophan degrading enzyme, and high cortisol levels induce high tryptophan oxygenase activity, which in turn increases metabolism along the tryptophannicotinic acid pathway. These results suggest that persistent immune activation and intense adrenal activity occur in patients with cancer cachexia, resulting in disorders involving tryptophan metabolism followed by depression in cancer cahexia.
| Original language | English |
|---|---|
| Pages (from-to) | 233-236 |
| Number of pages | 4 |
| Journal | Acta Medica Okayama |
| Volume | 51 |
| Issue number | 4 |
| Publication status | Published - Aug 1997 |
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Keywords
- Cancer cachexia
- Cortisol
- Neopterin
- Neuro-endocrine-immune interaction
- Serotonin
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Cancer Cachexia and Depressive States : A Neuro-Endocrine-Immunological Disease? / Iwagaki, Hiromi; Hizuta, Akio; Uomoto, Masashi; Takeuchi, Yoshiaki; Saito, Shinya; Tanaka, Noriaki.
In: Acta Medica Okayama, Vol. 51, No. 4, 08.1997, p. 233-236.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cancer Cachexia and Depressive States
T2 - A Neuro-Endocrine-Immunological Disease?
AU - Iwagaki, Hiromi
AU - Hizuta, Akio
AU - Uomoto, Masashi
AU - Takeuchi, Yoshiaki
AU - Saito, Shinya
AU - Tanaka, Noriaki
PY - 1997/8
Y1 - 1997/8
N2 - Plasma 5-hydroxytryptamine (serotonin), tryptophan, neopterin and cortisol levels were measured in patients with depressive cancer cachexia and in healthy controls during the same time period. Patients with advanced cancers had significantly raised neopterin, a marker of endogenous gamma-interferon (IFN-γ) production, and cortisol values, but decreased serotonin and tryptophan levels. Much work has been done to elucidate the possible role of serotonin in depressive states. IFN-γ induces a high level of indoleamine dioxygenase (IDO), a tryptophan degrading enzyme, and high cortisol levels induce high tryptophan oxygenase activity, which in turn increases metabolism along the tryptophannicotinic acid pathway. These results suggest that persistent immune activation and intense adrenal activity occur in patients with cancer cachexia, resulting in disorders involving tryptophan metabolism followed by depression in cancer cahexia.
AB - Plasma 5-hydroxytryptamine (serotonin), tryptophan, neopterin and cortisol levels were measured in patients with depressive cancer cachexia and in healthy controls during the same time period. Patients with advanced cancers had significantly raised neopterin, a marker of endogenous gamma-interferon (IFN-γ) production, and cortisol values, but decreased serotonin and tryptophan levels. Much work has been done to elucidate the possible role of serotonin in depressive states. IFN-γ induces a high level of indoleamine dioxygenase (IDO), a tryptophan degrading enzyme, and high cortisol levels induce high tryptophan oxygenase activity, which in turn increases metabolism along the tryptophannicotinic acid pathway. These results suggest that persistent immune activation and intense adrenal activity occur in patients with cancer cachexia, resulting in disorders involving tryptophan metabolism followed by depression in cancer cahexia.
KW - Cancer cachexia
KW - Cortisol
KW - Neopterin
KW - Neuro-endocrine-immune interaction
KW - Serotonin
UR - http://www.scopus.com/inward/record.url?scp=0031202063&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031202063&partnerID=8YFLogxK
M3 - Article
C2 - 9284972
AN - SCOPUS:0031202063
VL - 51
SP - 233
EP - 236
JO - Acta Medica Okayama
JF - Acta Medica Okayama
SN - 0386-300X
IS - 4
ER -