Camostat, an oral trypsin inhibitor, reduces pancreatic fibrosis induced by repeated administration of a superoxide dismutase inhibitor in rats

Yasuyuki Emori, Takaaki Mizushima, Naoki Matsumura, Koji Ochi, Hiroaki Tanioka, Akinori Shirahige, Mitsuko Ichimura, Toshiyuki Shinji, Norio Koide, Mitsune Tanimoto

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Background and Aim: An oral trypsin inhibitor, camostat (CM), has a beneficial effect on chronic pancreatitis, but its mechanism is not yet fully understood. Recently, pancreatic stellate cells (PSC) have been reported to play an essential role in pancreatic fibrosis. An experimental model of pancreatic fibrosis induced by a superoxide dismutase (SOD) inhibitor (diethyldithiocarbamate [DDC]) was developed in rats. Thus, the effect of an oral trypsin inhibitor on pancreatic fibrosis and PSC was investigated. Methods: Pancreatic fibrosis was induced in rats using DDC (DDC rats). DDC + CM rats were administered DDC, and subsequently were fed a diet containing CM. Immunohistochemistry of the pancreas was performed with monoclonal anti-α-smooth muscle actin (α-SMA) antibody and antidesmin antibody. Results: The DDC rats showed a significant increase in α-SMA-positive cells or desmin-positive cells compared with control rats. These significant increases in the fibrotic area improved after treatment with CM. The level of prolyl hydroxylase in the pancreas, which significantly increased as a result of DDC, decreased after treatment with CM. Conclusion: Camostat has a beneficial effect on pancreatic fibrosis induced by the administration of a SOD inhibitor, which inhibits the proliferation and activation of PSC.

Original languageEnglish
Pages (from-to)895-899
Number of pages5
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume20
Issue number6
DOIs
Publication statusPublished - Jun 2005

Keywords

  • Camostat
  • Diethyldithiocarbamate
  • Fibrosis
  • Pancreas
  • Pancreatic stellate cells
  • Prolyl hydroxylase

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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