Calretinin-containing neurons which co-express parvalbumin and calbindin D-28k in the rat spinal and cranial sensory ganglia; Triple immunofluorescence study

H. Ichikawa, H. W. Jin, R. Terayama, T. Yamaai, D. M. Jacobowitz, T. Sugimoto

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The co-expression of calretinin with parvalbumin and calbindin D-28k was examined in the rat cranial and spinal sensory ganglia by triple immunofluorescence method. In the trigeminal and nodose ganglia, 9% and 5% of calretinin-immunoreactive neurons, respectively, also contained both parvalbumin- and calbindin D-28k immunoreactivity. These neurons had large cell bodies. In the trigeminal ganglion, they were restricted to the caudal portion. Such neurons were evenly distributed throughout the nodose ganglion. The co-expression could not be detected in the dorsal root, jugular or petrosal ganglia. Nerve fibers which co-expressed all the three calcium-binding proteins were observed in the inferior alveolar nerve but not the infraorbital nerve or palate. In the periodontal ligament, these nerve fibers formed Ruffini-like endings. These findings suggest that (1) the co-expression in trigeminal neurons is intimately related to their peripheral receptive fields; (2) the three calcium-binding proteins (calretinin, parvalbumin, calbindin D-28k) co-expressed in the trigeminal neurons may have mechanoreceptive function in the periodontal ligament.

Original languageEnglish
Pages (from-to)118-123
Number of pages6
JournalBrain Research
Volume1061
Issue number2
DOIs
Publication statusPublished - Nov 9 2005

Fingerprint

Sensory Ganglia
Calbindin 2
Calbindins
Parvalbumins
Fluorescent Antibody Technique
Neurons
Nodose Ganglion
Trigeminal Ganglion
Periodontal Ligament
Nerve Fibers
Mandibular Nerve
Calcium-Binding Proteins
Palate
Spinal Nerve Roots
Spinal Ganglia
Ganglia
Neck

Keywords

  • Calbindin D-28k
  • Calretinin
  • Dorsal root ganglion
  • Jugular ganglion
  • Nodose ganglion
  • Parvalbumin
  • Petrosal ganglion
  • Trigeminal ganglion

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Calretinin-containing neurons which co-express parvalbumin and calbindin D-28k in the rat spinal and cranial sensory ganglia; Triple immunofluorescence study. / Ichikawa, H.; Jin, H. W.; Terayama, R.; Yamaai, T.; Jacobowitz, D. M.; Sugimoto, T.

In: Brain Research, Vol. 1061, No. 2, 09.11.2005, p. 118-123.

Research output: Contribution to journalArticle

Ichikawa, H. ; Jin, H. W. ; Terayama, R. ; Yamaai, T. ; Jacobowitz, D. M. ; Sugimoto, T. / Calretinin-containing neurons which co-express parvalbumin and calbindin D-28k in the rat spinal and cranial sensory ganglia; Triple immunofluorescence study. In: Brain Research. 2005 ; Vol. 1061, No. 2. pp. 118-123.
@article{b582732d9b9449d99a211b0f54080476,
title = "Calretinin-containing neurons which co-express parvalbumin and calbindin D-28k in the rat spinal and cranial sensory ganglia; Triple immunofluorescence study",
abstract = "The co-expression of calretinin with parvalbumin and calbindin D-28k was examined in the rat cranial and spinal sensory ganglia by triple immunofluorescence method. In the trigeminal and nodose ganglia, 9{\%} and 5{\%} of calretinin-immunoreactive neurons, respectively, also contained both parvalbumin- and calbindin D-28k immunoreactivity. These neurons had large cell bodies. In the trigeminal ganglion, they were restricted to the caudal portion. Such neurons were evenly distributed throughout the nodose ganglion. The co-expression could not be detected in the dorsal root, jugular or petrosal ganglia. Nerve fibers which co-expressed all the three calcium-binding proteins were observed in the inferior alveolar nerve but not the infraorbital nerve or palate. In the periodontal ligament, these nerve fibers formed Ruffini-like endings. These findings suggest that (1) the co-expression in trigeminal neurons is intimately related to their peripheral receptive fields; (2) the three calcium-binding proteins (calretinin, parvalbumin, calbindin D-28k) co-expressed in the trigeminal neurons may have mechanoreceptive function in the periodontal ligament.",
keywords = "Calbindin D-28k, Calretinin, Dorsal root ganglion, Jugular ganglion, Nodose ganglion, Parvalbumin, Petrosal ganglion, Trigeminal ganglion",
author = "H. Ichikawa and Jin, {H. W.} and R. Terayama and T. Yamaai and Jacobowitz, {D. M.} and T. Sugimoto",
year = "2005",
month = "11",
day = "9",
doi = "10.1016/j.brainres.2005.08.014",
language = "English",
volume = "1061",
pages = "118--123",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Calretinin-containing neurons which co-express parvalbumin and calbindin D-28k in the rat spinal and cranial sensory ganglia; Triple immunofluorescence study

AU - Ichikawa, H.

AU - Jin, H. W.

AU - Terayama, R.

AU - Yamaai, T.

AU - Jacobowitz, D. M.

AU - Sugimoto, T.

PY - 2005/11/9

Y1 - 2005/11/9

N2 - The co-expression of calretinin with parvalbumin and calbindin D-28k was examined in the rat cranial and spinal sensory ganglia by triple immunofluorescence method. In the trigeminal and nodose ganglia, 9% and 5% of calretinin-immunoreactive neurons, respectively, also contained both parvalbumin- and calbindin D-28k immunoreactivity. These neurons had large cell bodies. In the trigeminal ganglion, they were restricted to the caudal portion. Such neurons were evenly distributed throughout the nodose ganglion. The co-expression could not be detected in the dorsal root, jugular or petrosal ganglia. Nerve fibers which co-expressed all the three calcium-binding proteins were observed in the inferior alveolar nerve but not the infraorbital nerve or palate. In the periodontal ligament, these nerve fibers formed Ruffini-like endings. These findings suggest that (1) the co-expression in trigeminal neurons is intimately related to their peripheral receptive fields; (2) the three calcium-binding proteins (calretinin, parvalbumin, calbindin D-28k) co-expressed in the trigeminal neurons may have mechanoreceptive function in the periodontal ligament.

AB - The co-expression of calretinin with parvalbumin and calbindin D-28k was examined in the rat cranial and spinal sensory ganglia by triple immunofluorescence method. In the trigeminal and nodose ganglia, 9% and 5% of calretinin-immunoreactive neurons, respectively, also contained both parvalbumin- and calbindin D-28k immunoreactivity. These neurons had large cell bodies. In the trigeminal ganglion, they were restricted to the caudal portion. Such neurons were evenly distributed throughout the nodose ganglion. The co-expression could not be detected in the dorsal root, jugular or petrosal ganglia. Nerve fibers which co-expressed all the three calcium-binding proteins were observed in the inferior alveolar nerve but not the infraorbital nerve or palate. In the periodontal ligament, these nerve fibers formed Ruffini-like endings. These findings suggest that (1) the co-expression in trigeminal neurons is intimately related to their peripheral receptive fields; (2) the three calcium-binding proteins (calretinin, parvalbumin, calbindin D-28k) co-expressed in the trigeminal neurons may have mechanoreceptive function in the periodontal ligament.

KW - Calbindin D-28k

KW - Calretinin

KW - Dorsal root ganglion

KW - Jugular ganglion

KW - Nodose ganglion

KW - Parvalbumin

KW - Petrosal ganglion

KW - Trigeminal ganglion

UR - http://www.scopus.com/inward/record.url?scp=27744552016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27744552016&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2005.08.014

DO - 10.1016/j.brainres.2005.08.014

M3 - Article

C2 - 16242674

AN - SCOPUS:27744552016

VL - 1061

SP - 118

EP - 123

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -