Calretinin-containing neurons which co-express parvalbumin and calbindin D-28k in the rat spinal and cranial sensory ganglia; Triple immunofluorescence study

H. Ichikawa, H. W. Jin, R. Terayama, T. Yamaai, D. M. Jacobowitz, T. Sugimoto

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The co-expression of calretinin with parvalbumin and calbindin D-28k was examined in the rat cranial and spinal sensory ganglia by triple immunofluorescence method. In the trigeminal and nodose ganglia, 9% and 5% of calretinin-immunoreactive neurons, respectively, also contained both parvalbumin- and calbindin D-28k immunoreactivity. These neurons had large cell bodies. In the trigeminal ganglion, they were restricted to the caudal portion. Such neurons were evenly distributed throughout the nodose ganglion. The co-expression could not be detected in the dorsal root, jugular or petrosal ganglia. Nerve fibers which co-expressed all the three calcium-binding proteins were observed in the inferior alveolar nerve but not the infraorbital nerve or palate. In the periodontal ligament, these nerve fibers formed Ruffini-like endings. These findings suggest that (1) the co-expression in trigeminal neurons is intimately related to their peripheral receptive fields; (2) the three calcium-binding proteins (calretinin, parvalbumin, calbindin D-28k) co-expressed in the trigeminal neurons may have mechanoreceptive function in the periodontal ligament.

Original languageEnglish
Pages (from-to)118-123
Number of pages6
JournalBrain Research
Volume1061
Issue number2
DOIs
Publication statusPublished - Nov 9 2005

Keywords

  • Calbindin D-28k
  • Calretinin
  • Dorsal root ganglion
  • Jugular ganglion
  • Nodose ganglion
  • Parvalbumin
  • Petrosal ganglion
  • Trigeminal ganglion

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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